Reactivity Profile
1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL is incompatible with acids, acid chlorides and oxidizing agents.
Air & Water Reactions
Water soluble.
Potential Exposure
A specialty solvent for some poly mers; a lavatory reagent.
Fire Hazard
This chemical is probably combustible.
First aid
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respira tion with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and
isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin con tact, avoid spreading material on unaffected skin. Keep vic tim warm and quiet. Effects of exposure (inhalation,
ingestion or skin contact) to substance may be delayed.
Ensure that medical personnel are aware of the material(s)
involved and take precautions to protect themselves.
Medical observation is recommended for 24 to 48 hours
after breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or
authorized paramedic may consider administering a drug or
other inhalation therapy.
Shipping
UN1760 Corrosive liquids, n.o.s., Hazard class: 8;
Labels: 8-Corrosive material.
Incompatibilities
HFIP is incompatible with acids, acid
chlorides, and oxidizing agents.
Chemical Properties
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a
clear, colorless, oily, combustible liquid. Odor is described
as aromatic.
Chemical Properties
Colorless liquid
Waste Disposal
May be incinerated. In accor dance with 40CFR165, follow recommendations for the
disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by
contacting your local or federal environmental control
agency, or by contacting your regional EPA office. Consult
with environmental regulatory agencies for guidance on
acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA
regulations governing storage, transportation, treatment,
and waste disposal.
Uses
It is used as a polar solvent and exhibits strong hydrogen bonding properties.It dissolves substances that are hydrogen-bond acceptors, such as amides, ethers and a wide range of polymers, including those that are not soluble in the most common organic solvents.
Uses
1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.
Uses
Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry.
Uses
Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.
Definition
ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.
General Description
1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. It also enhances the efficiency of rhodium(I)-catalyzed [4+2] intramolecular cycloaddition of ether-tethered alkynyl dienes and [5+2] cycloaddition of alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications
storage
Color Code- White stripe (store separately):Contact Hazard; not compatible with materials in solidwhite category. Storage precautions: you should store thischemical in a refrigerator and keep it away from ox idizingmaterials. Store away from sources of ignition. Protectiveclothing (minimum protective clothing): if Tyvek-typedisposable protective clothing is not worn during handlingof this chemical, wear disposable Tyvek-type sleeves tapedto your gloves.
Purification Methods
Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.
