ChemicalBook CAS DataBase List 4-Morpholineethanesulfonic acid

4-Morpholineethanesulfonic acid

Product Name4-Morpholineethanesulfonic acid
CAS4432-31-9
CBNumberCB3100297
MFC6H13NO4S
MW195.24
EINECS224-632-3
MDL NumberMFCD00006181
MOL File4432-31-9.mol
MSDS FileSDS

Chemical Properties

Melting point	>300 °C(lit.)
Boiling point	102°C
Density	1.208 (estimate)
refractive index	1.5500 (estimate)
storage temp.	2-8°C
solubility	H₂O: 0.5 M at 20 °C, clear
pka	pKa at 0.1M ionic: 0°, 6.38; 20°, 6.15; 37°, 5.98; pKa1 1.99; pKa2 6.21; pKa/°C -0.011
form	Powder
color	White
PH	2.5-4.0 (25℃ in neat)
PH Range	5.5 - 6.7
Water Solubility	185.2g/L at 20℃
λmax	λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01
Merck	13,5929
BRN	6350956
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	SXGZJKUKBWWHRA-UHFFFAOYSA-N
LogP	-2.2 at 20℃
CAS DataBase Reference	4432-31-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	2GNK67Q0C4
EPA Substance Registry System	4-Morpholineethanesulfonic acid (4432-31-9)

Safety

Symbol(GHS)
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P271-P280
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25-22
WGK Germany	1
RTECS	QE9104530
HS Code	29349990

4-Morpholineethanesulfonic acid Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich 76039	100ML	$206	MES solution BioUltra, for molecular biology, 0.5?M in H2O	Buy
Sigma-Aldrich 475893	100G	$115	MES, Free Acid, ULTROL® Grade A zwitterionic buffer useful in the pH range of 5.5-6.5. Has a pKa of 6.10 at 25°C. Absorbance (1.0 M, H2O, 260 nm):0.05.	Buy
Sigma-Aldrich 76039	500ML	$818	MES solution BioUltra, for molecular biology, 0.5?M in H2O	Buy
Sigma-Aldrich 475893	500G	$561	MES, Free Acid, ULTROL® Grade A zwitterionic buffer useful in the pH range of 5.5-6.5. Has a pKa of 6.10 at 25°C. Absorbance (1.0 M, H2O, 260 nm):0.05.	Buy
Sigma-Aldrich 475893	1KG	$787	MES, Free Acid, ULTROL® Grade A zwitterionic buffer useful in the pH range of 5.5-6.5. Has a pKa of 6.10 at 25°C. Absorbance (1.0 M, H2O, 260 nm):0.05.	Buy

4-Morpholineethanesulfonic acid Chemical Properties,Usage,Production

Application

4-Morpholineethanesulfonic acid (MES) is one of the good′s buffers, and the most extensively application is biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring and it does not form complexes with the majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes. MES has been also used as a component of the elution buffer used to elute plasma from α2-macroglobulin affinity column. It has been used as an activation buffer during antibody conjugation to microparticles and it has been used in the functionalization of microchannels during the creation of microfluidic-integrated surface plasmon resonance (SPR) platform for pathogen detection.

Chemical Properties

White/clear crystalline powder

Uses

MES solution has been used to activate microspheres. It has also been used as a component of activating solution to activate carboxyl groups of poly lactic-co-glycolic acid (PLGA).

Uses

Biological buffer.

Definition

ChEBI: 2-(N-morpholino)ethanesulfonic acid is a Good's buffer substance, pKa = 6.15 at 20 ℃. It is an organosulfonic acid and a MES. It is a conjugate acid of a 2-(N-morpholino)ethanesulfonate. It is a tautomer of a 2-(N-morpholiniumyl)ethanesulfonate.

General Description

MES is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. It does not form complexes with majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes.

Flammability and Explosibility

Not classified

storage

Store at RT

Purification Methods

Crystallise MES from hot EtOH containing a little water. The picrate crystallises from EtOH and has m 178.8-182o. [Malkiel & Mason J Org Chem 8 199 1943, Beilstein 27 III/IV 370.]

4-Morpholineethanesulfonic acid synthesis

Preparation Products And Raw materials

4-Morpholineethanesulfonic acid Supplier

Supplier	Tel	Email	Country	ProdList	Advantage
Tangshan Moneide Trading Co., Ltd.	+86-315-8309571 +8615633399667	sales@moneidechem.com	China	574	58
Jiangsu Boquan Biotechnology Co., Ltd.	+86-18168774353	boquanshengwu003@boquansw.com	China	248	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18151	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20284	58
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	852	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+8615350851019	admin@86-ss.com	China	1001	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58

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4-Morpholineethanesulfonic acid

Chemical Properties

Safety

4-Morpholineethanesulfonic acid Price

4-Morpholineethanesulfonic acid Chemical Properties,Usage,Production

4-Morpholineethanesulfonic acid synthesis

Preparation Products And Raw materials

4-Morpholineethanesulfonic acid Supplier

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