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4-Morpholineethanesulfonic acid

Basic information Application Safety Related Supplier
4-Morpholineethanesulfonic acid Basic information
4-Morpholineethanesulfonic acid Chemical Properties
  • Melting point:>300 °C(lit.)
  • Boiling point:102°C
  • Density 1.208 (estimate)
  • refractive index 1.5500 (estimate)
  • storage temp. Store at RT.
  • solubility H2O: 0.5 M at 20 °C, clear
  • pkapKa at 0.1M ionic: 0°, 6.38; 20°, 6.15; 37°, 5.98; pKa1 1.99; pKa2 6.21; pKa/°C -0.011
  • form Powder
  • color White
  • PH2.5-4.0 (25℃ in neat)
  • PH Range5.5 - 6.7
  • λmaxλ: 260 nm Amax: 0.01
    λ: 280 nm Amax: 0.01
  • Merck 13,5929
  • BRN 6350956
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • InChIKeySXGZJKUKBWWHRA-UHFFFAOYSA-N
  • CAS DataBase Reference4432-31-9(CAS DataBase Reference)
  • EPA Substance Registry System4-Morpholineethanesulfonic acid (4432-31-9)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36-24/25-22
  • WGK Germany 1
  • RTECS QE9104530
  • HS Code 29349990
MSDS
4-Morpholineethanesulfonic acid Usage And Synthesis
  • Application

    4-Morpholineethanesulfonic acid (MES) is one of the good′s buffers, and the most extensively application is biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring and it does not form complexes with the majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes. MES has been also used as a component of the elution buffer used to elute plasma from α2-macroglobulin affinity column. It has been used as an activation buffer during antibody conjugation to microparticles and it has been used in the functionalization of microchannels during the creation of microfluidic-integrated surface plasmon resonance (SPR) platform for pathogen detection.

  • Chemical PropertiesWhite/clear crystalline powder
  • UsesBiological buffer.
  • Purification MethodsCrystallise MES from hot EtOH containing a little water. The picrate crystallises from EtOH and has m 178.8-182o. [Malkiel & Mason J Org Chem 8 199 1943, Beilstein 27 III/IV 370.]
4-Morpholineethanesulfonic acid Preparation Products And Raw materials
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