PROCYANIDIN B2

Uses

Procyanidin B2 is a selective protein kinase C inhibitor and was also found to promote hair epithelial cell growth and stimulate anagen induction. Procyanidin B2 extracted from apples have also shown anti-inflammatory activities.

Definition

ChEBI: Procyanidin B2 is a proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 8' in a beta-configuration. Procyanidin B2 can be found in Cinchona pubescens (Chinchona, in the rind, bark and cortex), in Cinnamomum verum (Ceylon cinnamon, in the rind, bark and cortex), in Crataegus monogyna (Common hawthorn, in the flower and blossom), in Uncaria guianensis (Cat's claw, in the root), in Vitis vinifera (Common grape vine, in the leaf), in Litchi chinensis (litchi, in the pericarp), in the apple, in Ecdysanthera utilis and in red wine. It has a role as a metabolite and an antioxidant. It is a hydroxyflavan, a proanthocyanidin, a biflavonoid and a polyphenol. It is functionally related to a (-)-epicatechin.

Biological Activity

Polyphenolic plant compound th at exhibits anti-inflammatory, anti-cancer, antiviral, and antioxidant properties.

Procyanidin B2 is a polyphenolic plant compound th at exhibits anti-inflammatory, anti-cancer, antiviral, and antioxidant properties. Procyanidin B2 attenuates dyslipidemia, hyperglycemia, and oxidative stress in individuals with metabolic syndrome. Apparently, it reduces fatty liver by remodeling intestinal flora in a high-fat-cholesterol diet fed rabbits.