Biochemical Application Industrial Uses Applications in cosmetics
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Biochemical Application Industrial Uses Applications in cosmetics
TRIOLEIN Structure
  • CAS No.122-32-7
  • Chemical Name:TRIOLEIN
  • CBNumber:CB2715065
  • Molecular Formula:C57H104O6
  • Formula Weight:885.43
  • MOL File:122-32-7.mol
  • Melting point: :-5,5°C
  • Boiling point: :235-240 °C18 mm Hg(lit.)
  • Density  :0.91 g/mL(lit.)
  • refractive index  :n20/D 1.470
  • Flash point: :330 °C
  • storage temp.  :-20°C
  • solubility  :chloroform: 0.1 g/mL, clear, colorless
  • form  :Liquid
  • color  :Clear Pale Yellow
  • Merck  :14,9732
  • BRN  :1718692
  • Stability: :Stability Stable, but air and light sensitive. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference :122-32-7(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :O05EC62663
  • EPA Substance Registry System :9-Octadecenoic acid (9Z)-, 1,1',1''-(1,2,3-propanetriyl) ester (122-32-7)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H302+H312+H332
  • Precautionary statements P210-P280
TRIOLEIN Price More Price(19)
  • Brand: Sigma-Aldrich
  • Product number: 92860
  • Product name : Glyceryl trioleate
  • Purity: ≥97.0% (TLC)
  • Packaging: 5ml
  • Price: $80
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 41679
  • Product name : Glyceryl trioleate
  • Purity: analytical standard
  • Packaging: 100mg
  • Price: $81.5
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: Y0001113
  • Product name : Triolein
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: G0089
  • Product name : Triolein
  • Purity: >80.0%(GC)
  • Packaging: 25g
  • Price: $95
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: G0089
  • Product name : Triolein
  • Purity: >80.0%(GC)
  • Packaging: 100g
  • Price: $237
  • Updated: 2021/03/22
  • Buy: Buy

TRIOLEIN Chemical Properties,Usage,Production

  • Biochemical Application

    Glyceryl trioleate is derived from glycerol. It is composed of three oleic acid units and is an unsaturated triglyceride. Glyceryl trioleate has been used as an experimental diet along with fat-free basal mix and corn oil and then to access the dietary fat absorption among mice, as an interfering substance to test its effect on human serum in the approach to develop rapid enzyme immunoassay for the detection of retinol-binding protein, and as a standard in the determination of triglyceride concentration, colorimetrically using liver tissue sample from cows, and so on.

  • Industrial Uses

    Triolein can be used as a textile finishing agent in textile industry, also used as additive in pigment grind. In pharm industry, it is used as an ointment, emulsifiable paste, suppository, lotion, emulsifier in air agent, stabilizing agent, lubricating agent, antifoaming agents. In food industry, it has the function as emulsify, disperse, defoaming, blister, antistaling of starch and control fat agglutination, usually used as an agent in candy, ice cream, cookie and bread. When triolein is used in beverage, could avoid ester to float, and avoid protein to sink, therefore to improve stability. When used in bread, cookie, could improve organization structure, increase volume, antistaling, prolongs warranty validity.

  • Applications in cosmetics
    Triolen is widely used as the ingredients in cosmetics. Triolein has oleic acid in its structure, which is very beneficial for the skin. It is a skin-conditioning agent because it moisturizes the skin and forms a film over the skin. It can be used as a viscosity controlling agent, helps provide the desirable viscosity for a product, so it is used in body care, skin care and hair care products, toiletries, makeup products, and decorative cosmetics.
    The Cosmetic Ingredient Review (CIR) Expert Panel found that dermal application of triolein was not associated with significant irritation, and no evidence of sensitization or photosensitization was observed. Ocular exposures were found to be only mildly irritating to eyes. Triolein has not been found to be genotoxic in a number of in vitro and in vitro assay systems. 
  • Chemical Properties colourless viscous liquid
  • Chemical Properties Triolein occurs as a clear, colorless to yellowish oily liquid, and is tasteless and odorless.
  • Definition ChEBI: A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.
  • Production Methods Triolein is manufactured by the esterification of fractionated fatty acids, mainly oleic acid and glycerin.
  • Pharmaceutical Applications Triolein is used as a solubilizer and solvent in injectable preparations. It has been used in marketed preparations of sustained-release injections of cytarabine and multivesicular liposomal injections of morphine sulfate. It has also been used in enteric coatings for oral preparations in combination with other enteric coating excipients to protect against degradation by pancreatic lipase.
    Triolen is used in personal care products as a skin-conditioning and viscosity-controlling agent.
  • Safety Triolein is used in injectable preparations, in enteric coatings for oral preparations, and in personal care products. Chronic exposure may cause nausea and vomiting, and higher exposures may cause unconsciousness.
    The Cosmetic Ingredient Review (CIR) Expert Panel found that dermal application of triolein was not associated with significant irritation, and no evidence of sensitization or photosensitization was observed. Ocular exposures were found to be only mildly irritating to eyes. Triolein has not been found to be genotoxic in a number of in vitro and in vitro assay systems. Subcutaneous injections of triolein in rats showed no tumors at the injection site. The CIR Expert Panel also noted that metabolism data indicated that glyceryl triesters (including triolein) followed the same metabolic pathways as fats in food. They were split into monoglycerides, free fatty acids, and glycerol, all of which were absorbed into the intestinal mucosa and metabolized further. Therefore, oral exposure to these compounds was not found to be a concern.
    A triolein-based amphotericin emulsion showed better safety with a higher LD50 in rats as compared with the conventional amphotericin deoxycholate.
  • storage Triolein is classified as a stable compound but is sensitive to air and light. It should be stored in tightly sealed containers in a dry area at 2–8℃. Thermal decomposition of triolein may lead to release of irritating gases and vapors such as carbon oxides. Exposure to air and moisture over prolonged periods should be avoided.
  • Incompatibilities Triolein is incompatible with strong oxidizing agents and spontaneously flammable products. Being a triglyceride ester, triolein can be hydrolyzed by strong acids, and particularly by strong bases. It is possible for primary amines to form an adduct across the olefinic double bonds (analogous to a Michael addition).
  • Regulatory Status Included in the FDA Inactive Ingredients Database (liposomal suspension for epidural injections). Included in parenteral medicines (suspension for intrathecal injection) licensed in the UK.
    Triolein is included in the CIR category as safe for use in cosmetics and personal care products. Its use as an indirect food additive has been approved by the FDA.
TRIOLEIN Preparation Products And Raw materials
Raw materials
Preparation Products
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    BOC Sciences
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    Chongqing Chemdad Co., Ltd
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