6-Chloro-3-iodo-imidazo[1,2-a]pyridine

Uses

Synthesis

6188-25-6

885275-59-2

General procedure for the synthesis of 6-chloro-3-iodoimidazo[1,2-a]pyridine from 6-chloroimidazo[1,2-A]pyridine: To a solution of 6-chloroimidazo[1,2-A]pyridine (500.00 mg, 3.28 mmol) in N,N-dimethylformamide (DMF, 10 mL) at 0 °C was added N-iodosuccinimide (NIS, 884.70 mg, 3.94 mmol). The reaction mixture was slowly warmed to 20 °C and stirred continuously for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated sodium bicarbonate solution (20 mL) and stirring was continued for 1 hour. The resulting solid product was collected by filtration and dried in an oven to afford the target compound 6-chloro-3-iodoimidazo[1,2-a]pyridine (900.00 mg, 3.23 mmol). The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts of δH 8.20 (s, 1H), 7.72 (s, 1H), 7.57 (d, 1H), 7.21 (dd, 1H).

References