Uses
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715)[1][2].
in vivo
Ranatensin (10-50 μg/mL, 0.1-1 mL; i.v.; single dose) increases blood pressure in the dog and rabbit, indicating a direct peripheral vasoconstrictor action[2].
Ranatensin (10-50 μg/mL, 0.1-1 mL; i.v.; single dose) also lowers blood pressure in the monkey, being as potent as Eledoisin (HY-P0006). It show a direct peripheral action on vascular smooth muscle[2].
Ranatensin (10-50 μg/mL, 0.005-0.1 mL; i.v.; single dose) has a variable effect based on the basal level of blood pressure in the rat that shows antihypertensive efffect during high level and raises blood pressure when level is low, in part due to the release of noradrenaline from peripheral sympathetic nerve endings[2].
References
[1] Jensen RT, et al. A synthetic peptide that is a bombesin receptor antagonist. Nature. 1984 May 3-9;309(5963):61-3. DOI:
10.1038/309061a0[2] Geller RG, et al. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16. DOI:
10.1111/j.1476-5381.1970.tb10641.x
