Description
Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.
Originator
Janssen (Belgium)
Uses
Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.
Definition
ChEBI: Thymopentin is an oligopeptide.
brand name
SINTOMODULINA; TIMUNOX
Clinical Use
Thymopentin is a synthetic, immunomodulating pentapeptide, representing the
active fragment of the thymus hormone, thymopoietin. Thymopentin induces
phenotypic differentiation and maturation of T-cells. It appears of value in the
treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis,
sarcoidosis and a variety of other diseases with manifestations of disturbed
immune balance.
References
Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.
