RANATENSIN

Ranatensin (10-50 μg/mL, 0.1-1 mL; i.v.; single dose) increases blood pressure in the dog and rabbit, indicating a direct peripheral vasoconstrictor action^[2].
Ranatensin (10-50 μg/mL, 0.1-1 mL; i.v.; single dose) also lowers blood pressure in the monkey, being as potent as Eledoisin (HY-P0006). It show a direct peripheral action on vascular smooth muscle^[2].
Ranatensin (10-50 μg/mL, 0.005-0.1 mL; i.v.; single dose) has a variable effect based on the basal level of blood pressure in the rat that shows antihypertensive efffect during high level and raises blood pressure when level is low, in part due to the release of noradrenaline from peripheral sympathetic nerve endings^[2].