Synthesis
General method: 5-Bromovaleric acid (1 eq.) and triphenylphosphine (1 eq.) were dissolved in 300 mL of toluene and the reaction was refluxed under argon protection for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The target product 4-carboxybutyltriphenylphosphonium bromide was obtained by crystallization and purification of the residue from a suitable solvent.
References
[1] Journal of Organic Chemistry, 1999, vol. 64, # 9, p. 3196 - 3206
[2] Canadian Journal of Chemistry, 2003, vol. 81, # 6, p. 697 - 704
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 1, p. 567 - 579
[4] Journal of Organic Chemistry, 1987, vol. 52, # 20, p. 4449 - 4453
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6353 - 6363
