Triphenylphosphine hydrobromide

Chemical Properties

white to light beige crystalline powder or chunks

Uses

Triphenylphosphine hydrobromide is the hydrobromide salt of Triphenylphosphine, used in the preparation of uridine derivatives as substrate donor analogs of UDP-sugars for glycosyltransferases. Also used in the preparation of tensioactive and antibacterial deoxyglycoside compounds via catalysis.

Uses

Triphenylphosphine hydrobromide is used as mild source of anhydrous HBr; catalyst for formation of THP ethers from tertiary alcohols; preparation of phosphonium salts.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling

Synthesis

The Preparative Method of Triphenylphosphine Hydrobromide: addition of anhydrous Hydrogen Bromide to an ethereal solution of Triphenylphosphine; addition of Ph3P to 48% aqueous HBr followed by CHCl3 extraction and drying.