Uses
2-Amino-5-bromothiazole is a type of aliphatic hydrocarbon that has been synthesized by Friedel-Crafts acylation. This chemical is used to neutralize typhimurium and can be used in the synthesis of other compounds. The functional theory on how 2-amino-5-bromothiazole works may be due to its ability to form nitro groups, which are highly reactive and cause depression in the reaction scheme. 2-Amino-5-bromothiazole is often used as a test organism for other organisms in order to measure their sensitivity to different types of chemicals. It has also been shown that it has an effect on hydrocarbons, which have been shown to have an effect on organisms such as bacteria.
Synthesis
General procedure for the synthesis of 2-amino-5-bromothiazole from 2-amino-5-bromothiazole hydrobromide: A suspension of 2-amino-5-bromothiazole hydrobromide (30.0 g, 116.35 mmol) and triethylamine (TEA, 24.1 mL, 174.53 mmol) in tetrahydrofuran (THF, 350 mL) was stirred for 6 hours at room temperature. Upon completion of the reaction, the resulting precipitate was removed by filtration and the filtrate was concentrated under reduced pressure to afford 2-amino-5-bromothiazole (17 g, 94.97 mmol). The resulting product could be used directly in the subsequent reaction without further purification.
References
[1] Patent: WO2015/52226, 2015, A1. Location in patent: Paragraph 0455
[2] Patent: WO2004/72066, 2004, A1. Location in patent: Page 33-34
[3] Patent: WO2007/2181, 2007, A2. Location in patent: Page/Page column 128-129
[4] Patent: WO2017/109488, 2017, A1. Location in patent: Page/Page column 47
