Chemical Properties
brown crystalline powder, grains, lumps or flakes
Uses
Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.
Uses
2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds.
Definition
ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 693, 1954
DOI: 10.1021/ja01632a016
General Description
Light brown crystals or brown granular solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides.
Fire Hazard
Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible.
Biochem/physiol Actions
2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders.
Safety Profile
Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi
Purification Methods
It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.]
