Description
Isopimaric acid (5835-26-7) is a terpenoid acid that activates BK (voltage-gated potassium) channels when used at 10 μM in HEK293 cells.1 Improves spatial and non-spatial memory in Alzheimer’s mouse model2,3, and significantly improves motor function in a rat spinal cord injury model4. Reduces hyperactivity of spontaneously active auditory networks, EC50=7.8 μM.5
Definition
ChEBI: Isopimaric acid is a diterpenoid, a carbotricyclic compound and a monocarboxylic acid. It is a conjugate acid of an isopimarate. It derives from a hydride of an isopimara-7,15-diene.
General Description
Isopimaric acid, a resin acid produced by conifer trees, is a tricyclic diterpene compound. High levels of isopimaric acid in the hepatocytes of the rainbow trout may impair calcium signalling machinery. Isopimaric acid is a potential big potassium (BK) channel opener.
References
[1] YUJI IMAIZUMI. Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit.[J]. Molecular Pharmacology, 2002, 62 4: 836-846. DOI:
10.1124/mol.62.4.836[2] LI WANG . Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer’s disease[J]. Neuropharmacology, 2015, 92: Pages 8-15. DOI:
10.1016/j.neuropharm.2014.12.033[3] FURONG WANG . Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer’s disease model mice[J]. Neuropharmacology, 2015, 97: Pages 210-219. DOI:
10.1016/j.neuropharm.2015.05.027[4] MARIANNE JACOBSEN. Activation of the Large-Conductance, Voltage, and Ca2+- Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat Is Neuroprotective.[J]. Frontiers in Neurology, 2018: 1107. DOI:
10.3389/fneur.2018.01107[5] CALVIN WU . Pharmacodynamics of potassium channel openers in cultured neuronal networks[J]. European journal of pharmacology, 2014, 732: Pages 68-75. DOI:
10.1016/j.ejphar.2014.03.017
