Biological Activity
Dehydroevodiamine is the major alkaloid of Evodia rutaecarpa th at exhibit cardiovascular effects such as bradycardia, hypotension, and vasorelaxation. Dehydroevodiamine potently inhibits hERG channels. Apparently it is a blocker of IKr (rapid delayed rectifier current) with proarrhythmic effects in vitro and in vivo. Dehydroevodiamine ameliorates the spatial memory impairment in the scopolamine-induced amnestic rats. It reduced neurotoxicity and the production of A?-induced ROS in primary cortical neurons.
