Name | Dehydroevodiamine hydrochloride |
Description | Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production. |
Animal Research | The effects of dehydroevodiamine·HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats. |
In vivo | Dehydroevodiaminehydrochloride has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 37 mg/mL (109.53 mM)
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Keywords | inhibit | Inhibitor | Dehydroevodiamine Hydrochloride | Dehydroevodiamine hydrochloride | Dehydroevodiamine |
Inhibitors Related | 1-Naphthyl acetate | DL-Menthol | Ethyl (triphenylphosphoranylidene) acetate | 4-Methylbenzylidene camphor | Isoeugenol acetate | Diethyltoluamide | sn-Glycero-3-phosphocholine | Nizatidine | Coumaran | Methyl tridecanoate | Trimethylammonium chloride | Trimyristin |
Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Neurodegenerative Disease Compound Library | Alkaloid Natural Product Library | Natural Product Library | Neuroprotective Compound Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max |