Chemical Properties
Boiling point 100-107 ℃ (0.4kPa).
Uses
1-N-Ethoxycarbonyl-3-pyrrolidone can be used as a pharmaceutical intermediate.
Synthesis
Glycine is added to acrylonitrile to obtain N-cyanoethylglycine, which is esterified with ethanol and condensed with methyl ethyl chloroformate to form N-ethoxycarbonyl-N-ethoxycarbonylethylglycine ethyl ester, which is then cyclized , hydrolysis and elimination to obtain 1-ethoxycarbonylpyrrolidin-3-one.
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4609 - 4619
[2] Patent: WO2009/140467, 2009, A1. Location in patent: Page/Page column 29