Ethyl 8-bromooctanoate

Uses

Ethyl 8-bromooctanoate is a useful research reagent for organic synthesis and other chemical processes.

Synthesis

The synthesis method of ethyl 8-bromooctanoate: 1, 6-dibromohexane initial raw material is firstly used for carrying out substitution reaction with diethyl malonate to generate 2- (6-bromohexyl) diethyl malonate, and then ester hydrolysis and decarboxylation reaction are carried out to obtain the 8-bromooctanoic acid; and finally, esterification reaction is carried out to generate the compound 8-bromoethyl octanoate.

Toxics Screening Level

The initial threshold screening level (ITSL) for ethyl-8-bromooctanoate is 0.1 μg/m3 based on an annual averaging time.

References

[1] Tetrahedron Letters, 2001, vol. 42, # 2, p. 301 - 303
[2] Patent: US2003/228275, 2003, A1. Location in patent: Page 42
[3] Patent: US2003/229009, 2003, A1. Location in patent: Page 38
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 3, p. 563 - 566
[5] Synthesis, 1998, # 11, p. 1662 - 1669