Uses
Methazole is an herbicide used on fungus in the protection of crops.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.
Definition
ChEBI: Methazole is a dichlorobenzene.
Production Methods
The industrial synthesis of methazole typically begins with the construction of a 1,3,4-oxadiazole ring, a five-membered heterocycle containing nitrogen and oxygen atoms. This ring is formed via cyclisation reactions involving hydrazides and carboxylic acid derivatives under dehydrating conditions. Once the oxadiazole core is established, it is coupled with a chlorinated phenyl group, often through nucleophilic aromatic substitution or Friedel–Crafts-type reactions, to yield the herbicidal structure. The synthesis is carried out in organic solvents like acetonitrile or dichloromethane, with temperature and pH carefully controlled to ensure high yield and purity.
General Description
Colorless crystals to light tan solid. Non corrosive. Herbicide.
Air & Water Reactions
Hydrolyzed by strong acids and bases.
Reactivity Profile
MEETHAZOLE is an oxadiazole.
Mechanism of action
Selective. Methazole demonstrates selective phytotoxic activity through inhibition of photosynthetic electron transport which induces stunting and chlorosis
Safety Profile
Moderately toxic by ingestion.When heated to decomposition it emits very toxic fumesof Cl-and NOx.
