N-Boc-2-piperidone

Chemical Properties

Off-White Low Melting Solid

Uses

N-Boc-2-piperidone(85908-96-9) is used as a synthetic intermediate in the preparation of various biological inhibitors.

Preparation

4-Benzensulfonylmethyl-4-hydroxy-piperidine TFA (B-1) Diisopropylethylamine (28.3 mL, 162.75 mmol) and di-t-butyl dicarbonate (28.4 g, 130.02 mmol) were added in sequence to a mixture of piperidone hydrate hydrochloride (12) (10.0 g, 65.1 mmol) in methanol (50 mL).  The mixture was stirred at room temperature for 20 hours. After that, removed the solvent  and the remaining was separated with ether and 1 M KHSO₄ solution.  The organic layer was washed with brine and saturated NaHCO₃.  Finally, N-Boc-2-piperidone was obtained after purification.

Definition

ChEBI:N-Boc-2-piperidone-protected by t-Boc. It is also known as 1-N-Boc-2-piperidone,1-N-Boc-2-piperidone, or 1-(tert-Butoxycarbonyl)-2-piperidone.