Uses
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0nM and 442nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].
Biological Activity
Substrate site-targeting, non-cytotoxic, potent and selective human cyclic GMP-AMP synthase (cGAS) inhibitor against cellular STING signaling.
References
[1] Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261. DOI:
10.1038/s41467-019-08620-4