2369751-07-3

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0?nM and 442?nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].

Substrate site-targetingnon-cytotoxicpotent and selective human cyclic GMP-AMP synthase (cGAS) inhibitor against cellular STING signaling.

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[1] Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261. DOI:10.1038/s41467-019-08620-4