PKCα (C2-4) Inhibitor Peptide

Description

The C2 domain of conventional PKC isoforms mediates calcium-dependent translocation. Peptides from that region can block PKC translocation and inhibit function, both in cells and cell lysates. PKCα (C2-4) inhibitor peptide is a synthetic peptide that blocks PKC activity in HepG2 cells stimulated with calcium and pancreastatin when applied at 10 μM.

References

[1] JIAUR R GAYEN. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis.[J]. The Journal of Biological Chemistry, 2009: 28498-28509. DOI: 10.1074/jbc.m109.020636