Synthesis
N-Octyl pyrrolidone was synthesized by 2-pyrrolidone and tetrabutylammonium bromide stirred with adding n-octane chloride for 10 h at 90 °C.
Chemical Properties
Colorless or slightly yellow clear liquid
Uses
N-Octyl pyrrolidone(NOP) is a highly efficient and selective solvent, which can be used in the recovery of organic raw materials, the refining of lubricating oils, and the solvent for polymers and polymerization reactions; It is also widely used in chemical synthesis reactions.
Definition
ChEBI: N-Octyl-2-pyrrolidone is a N-alkylpyrrolidine.
Synthesis Reference(s)
The Journal of Organic Chemistry, 59, p. 6378, 1994
DOI: 10.1021/jo00100a046
Synthesis Reference(s)
The Journal of Organic Chemistry, 57, p. 3328, 1992
DOI: 10.1021/jo00038a019
General Description
1-Octyl-2-pyrrolidone is a permeation enhancer and its effect in transport of steroidal permeants across hairless mouse skin was investigated via a parallel pathway skin model.
Flammability and Explosibility
Non flammable
Safety Profile
Moderately toxic by ingestion. Asevere skin and eye irritant. A corrosive. Combustibleliquid. When heated to decomposition it emits toxic fumesof NOx.
