3-Bromopropylamine hydrobromide

Chemical Properties

white to off-white powder or chunks

Uses

3-Bromopropylamine hydrobromide is commonly used as a reagent to introduce propylamine group to the molecular skeleton. Some of the other reported applications include:

• Synthesis of photochemically and thermally reactive azobenzene rotaxane and indolocarbazole-containing [2]rotaxane.
• Synthesis of indenoisoquinoline based active topoisomerase I inhibitors as anticancer agents.

Uses

3-Bromopropylamine hydrobromide is used as pharmaceutical raw materials and intermediates. Homotaurine is synthesized from 3-bromopropylamine hydrobromide.

Synthesis

Add the mixture of 3-amino-1-propanol (1ml, 13.3mmol) and 48% HBr (10ml, 40mmol) into the round-bottomed flask and reflux for 15h. Water and HBr were then distilled from the mixture under vacuum. The mixture was further dried under vacuum through a KOH/CaCl column to give 3-Bromopropylamine hydrobromide (2.95 g, 100%) as a brown solid.