2-Butenoic acid, 2-methyl-, (5S,6S,7S,13aS)-5,6,7,13a-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-yl ester, (2Z)-

Description

Schisantherin B (STB) is a lignan originally isolated from S. sphenanthera fruit. It inhibits formation of advanced glycation end products (AGEs) in vitro. STB (0.1 mg/kg) decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer''s disease induced by amyloid-β (1-42) . It increases glial expression of glutamate transporter 1 (GLP-1) and decreases immobility time in the forced swim test (FST) in mice, indicating antidepressant-like activity. STB also increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST.

Uses

Schisantherin B is a bioactive of lignans isolated from Schisandra chinesis which protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice.

Definition

ChEBI: Gomisin B is a tannin.

target

P450 (e.g. CYP17) | GSK-3 | Beta Amyloid

References

[1] C S LIU. Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds.[J]. Scientia Sinica, 1978, 21 4: 483-502.
[2] B. POORNIMA . Advanced glycation end-products inhibitors isolated from Schisandra grandiflora[J]. Natural Product Research, 2016, 30 4: Pages 493-496. DOI: 10.1080/14786419.2015.1024117
[3] MENGJIE XU . Schisantherin B ameliorates Aβ1–42-induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer’s disease[J]. Physiology & Behavior, 2016, 167: Pages 265-273. DOI: 10.1016/j.physbeh.2016.09.018
[4] MENGJIE XU. Schisantherin B Improves the Pathological Manifestations of Mice Caused by Behavior Desperation in Different Ages-Depression with Cognitive Impairment.[J]. Biomolecules & Therapeutics, 2019, 27 2: 160-167. DOI: 10.4062/biomolther.2018.074