Description
Schisandrin A is a lignan that has been found in
Schisandra and has diverse biological activities. It binds to adiponectin receptor 2 (IC
50 = 3.2 μM). Schisandrin A (10, 20, and 50 μM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells. It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 μM. Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; ) in a mouse model of Alzheimer’s disease.
Chemical Properties
White powder
Uses
Schizandrin A is an extract from Schisandra chinesis. a dibenzocyclooctadiene lignan with antiinflammatory activity.
in vivo
Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and Vmax value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent Ki value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group)[2].
IC 50
CYP3A: 6.6 μM (IC
50); Autophagy
References
[1] YIYI SUN. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay.[J]. PLoS ONE, 2013: e63354. DOI:
10.1371/journal.pone.0063354[2] FANG-JIAO SONG. Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways[J]. PLoS ONE, 2016, 11 1. DOI:
10.1371/journal.pone.0149991[3] ZONG-LIN ZHANG Su R W Qing Cheng Jiang. Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation.[J]. Breast Cancer, 2018, 25 2: 233-242. DOI:
10.1007/s12282-017-0821-9[4] DI HU. Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβ-induced memory impairment in mice.[J]. Planta medica, 2012, 78 12: 1332-1336. DOI:
10.1055/s-0032-1315019
