Nelotanserin
- Product NameNelotanserin
- CAS380449-54-7
- CBNumberCB03159936
- MFC24H31Cl3FN3O3
- MW534.88
- MOL File380449-54-7.mol
- MSDS FileSDS
Nelotanserin Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| Biosynth FQA44954 | 5mg | $343.75 | Melflufen hydrochloride |
Buy |
| Biosynth FQA44954 | 10mg | $618.8 | Melflufen hydrochloride |
Buy |
| Biosynth FQA44954 | 25mg | $1031.25 | Melflufen hydrochloride |
Buy |
| Biosynth FQA44954 | 50mg | $1719 | Melflufen hydrochloride |
Buy |
| Biosynth FQA44954 | 100mg | $2750 | Melflufen hydrochloride |
Buy |
Nelotanserin Chemical Properties,Usage,Production
Uses
Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells[1][2][3].in vivo
Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model[1].
| Animal Model: | CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model)[1] |
| Dosage: | 3 mg/kg |
| Administration: | 1.v.; twice-weekly for two weeks |
| Result: | Significantly inhibited MM tumor growth and prolonged survival of mice. |
References
[1] Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013;19(11):3019-3031. DOI:10.1158/1078-0432.CCR-12-3752[2] Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016;174(3):397-409. DOI:10.1111/bjh.14065
[3] McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52. DOI:10.1186/s12943-019-0963-9
Preparation Products And Raw materials
Nelotanserin Suppliers
Global(23)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 15026964105 | 2881489226@qq.com | China | 87240 | 60 | |
| QQ：65489617 13301690235 |
Sales@ATKchemical.com | China | 9765 | 58 | |
| 400-9205774 400-920-5774 |
sales@glpbio.cn | China | 6705 | 58 | |
| 020-82000279 18988941452 |
YN_research@163.com | China | 2984 | 58 | |
| 17625585511 | 1580084073@qq.com | China | 999 | 58 | |
| 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 | |
| 400-1647117 13681763483 |
product02@bidepharm.com | China | 59929 | 58 | |
| 0371-65741762 | sales@hasunny.com | China | 2377 | 58 | |
| 4008200310 15002144251 |
marketing@tsbiochem.com | China | 24951 | 58 | |
| 021-65675885 18964387627 |
customer_service@efebio.com | China | 11963 | 58 |
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