Uses
Novel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles.
Uses
Trimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids.
Uses
As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.
Reactions
(1) Difluoromethylenation of TMSCN.
Ref. J. Org. Chem. 2012, 77, 5850?5855.
(2) Difluoromethylenation of benzyl and alkylzinc halides.
Ref. Org. Lett. 2013, 15, 917 – 919.
(3) Fluorination aminocarbonylation of aldehydes
Ref. Angew. Chem. Int. Ed. 2022, e202115467
General Description
(Bromodifluoromethyl)trimethylsilane (TMSCF
2Br) is commonly used as a source to generate dilfluorocarbene. TMSCF
3 (Ruppert–Prakash reagent) and BBr
3 undergoes fast halogen–exchange reaction to form MSCF
2Br.