Uses
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].
Definition
ChEBI: 7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one is a quinolone and a hydroxyquinoline.
Biological Activity
An antagonist at the glycine-NMDA site (IC 50 = 420 nM). Also a potent systemic anticonvulsant.
in vivo
L-701252 (50 mg/kg; i.p.) provides a small non-significant protection[1].
| Animal Model: | 3-Months Male Mongolian gerbils (60 g)[1] |
| Dosage: | 50 mg/kg |
| Administration: | i.p. |
| Result: | Provided a small non-significant protection. |
storage
Desiccate at +4°C
References
[1] Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. DOI:
10.1016/s0165-6147(00)01451-6[2] Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. DOI:
10.1016/s0006-8993(96)00779-2
