Description
D-
AP5 is a selective N-
methyl-
D-
aspartate (NMDA) receptor antagonist (K
d = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-
AP5 is the active (−)-
stereoisomer, its (+)-
isomer (L-
AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.
Chemical Properties
white fine crystalline powder
Uses
A competitive NMDA antagonist
General Description
Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.
Biological Activity
Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ .
Biochem/physiol Actions
Product does not compete with ATP.
References
[1] MORRIS R G. Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5.[J]. Journal of Neuroscience, 1989, 9 9: 3040-3057.
