Pheniraminhydrogenmaleat

Bezeichnung:Pheniraminhydrogenmaleat

CAS-Nr132-20-7

Englisch Name:Pheniramine maleate

CBNumberCB9727768

SummenformelC20H24N2O4

Molgewicht356.42

MOL-Datei132-20-7.mol

Synonyma

Pheniraminhydrogenmaleat

Pheniraminhydrogenmaleat physikalisch-chemischer Eigenschaften

Schmelzpunkt	104-108°C
Siedepunkt	489.25°C (rough estimate)
Dichte	1.2233 (rough estimate)
Brechungsindex	1.6800 (estimate)
storage temp.	2-8°C
Löslichkeit	Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
Aggregatzustand	Solid
Farbe	White
Wasserlöslichkeit	>=1 g/100 mL at 24 ºC
maximale Wellenlänge (λmax)	262nm(lit.)
Merck	14,7235
Stabilität	Stable. Incompatible with strong oxidizing agents.
CAS Datenbank	132-20-7(CAS DataBase Reference)
EPA chemische Informationen	Pheniramine maleate (132-20-7)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	UT0175000
HS Code	2933399090

Gefahreninformationscode (GHS)

Pheniramine maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white powder
Originator
Trimeton Maleate, Schering ,US,1948
Verwenden
Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.
Definition
ChEBI: Pheniramine maleate is an organic molecular entity.
Manufacturing Process
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the Pheniramine, BP 139°-142°C/1-2 mm. The Pheniramine maleate is produced by reaction with maleic acid.
Therapeutic Function
Antihistaminic
Allgemeine Beschreibung
Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.
Allgemeine Beschreibung
White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Brandgefahr
Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.
Biochem/physiol Actions
Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.
Nebenwirkungen
Drowsiness, dizziness, dry mouth/nose/throat, headache, upset stomach, constipation, or trouble sleeping may occur.

Pheniramine maleate Upstream-Materialien And Downstream Produkte

Pheniraminhydrogenmaleat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

132-20-7, Pheniramine maleate Verwandte Suche:

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