Pheniramin

Bezeichnung:Pheniramin

CAS-Nr86-21-5

Englisch Name:Pheniramine

CBNumberCB3192278

SummenformelC16H20N2

Molgewicht240.34

MOL-Datei86-21-5.mol

Synonyma

Pheniramin

Pheniramin physikalisch-chemischer Eigenschaften

Schmelzpunkt	<25 °C
Siedepunkt	bp13 181°; bp2 142°; bp0.5 135°
Dichte	1.0081
Brechungsindex	nD25 1.5519 to 1.5521
Flammpunkt	9℃
storage temp.	-20°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Oil
pka	pKa 4.03± 0.08;9.32± 0.06(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
Farbe	Colourless
InChIKey	IJHNSHDBIRRJRN-UHFFFAOYSA-N
CAS Datenbank	86-21-5(CAS DataBase Reference)
NIST chemische Informationen	Pyridine, 2[alpha-(2-dimethyl aminoethyl)benzyl](86-21-5)

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	11-23/24/25-39/23/24/25
S-Sätze:	16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1

Gefahreninformationscode (GHS)

Pheniramine Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Trimeton Maleate, Schering ,US,1948
Verwenden
Pheniramine is an antigripal drug. Also, it is derived from 2-Benzylpyridine (B288740), which is a benzylpyridine with antifungal properties. 2-Benzylpyridine is also used as a chromogenic reagent for micro determination of Molybednum.
Definition
ChEBI: N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine is a tertiary amino compound and a member of pyridines.
Manufacturing Process
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.
Therapeutic Function
Antihistaminic
Synthesis Reference(s)
The Journal of Organic Chemistry, 59, p. 7125, 1994 DOI: 10.1021/jo00102a044
Sicherheitsprofil
Poison by intravenous route. Human systemic effects by ingestion: central nervous system effects. When heated to decomposition it emits toxic fumes of NOx.
Enzyminhibitor
This antihistamine (FWfree-base = 240.35 g/mol; CAS 86-21-5; insoluble in water; maleate and p-aminosalicylate salts are water-soluble), also known as N,N-dimethyl-g-phenyl-2-pyridinepropanamide, is more frequently abused than other antihistamines relative to its market share. One of the histamine H1 antagonists with little sedative action, pheniramine is often used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. Target(s): H1 histamine receptor; and histamine Nmethyltransferase, mildly inhibited.

Pheniramine Upstream-Materialien And Downstream Produkte

Pheniramin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

86-21-5, Pheniramine Verwandte Suche:

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