Novobiocinnatrium

Bezeichnung:Novobiocinnatrium

CAS-Nr1476-53-5

Englisch Name:NOVOBIOCIN SODIUM SALT

CBNumberCB9493214

SummenformelC31H37N2NaO11

Molgewicht636.63

MOL-Datei1476-53-5.mol

Synonyma

Novobiocinnatrium

Novobiocinnatrium physikalisch-chemischer Eigenschaften

Schmelzpunkt	215-220 C
alpha	D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	H2O: soluble50mg/mL
Aggregatzustand	White to yellow solid
Farbe	white to faintly beige
PH	7.5 (100g/l, H2O, 25℃)
Optische Aktivität	[α]20/D 48±3°, c = 1% in ethanol
Wasserlöslichkeit	Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol.
Merck	13,6755
BRN	3892910
Stabilität	Hygroscopic

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	43-36-36/37/38-20/21/22
S-Sätze:	36-36/37-26-37/39
WGK Germany	2
RTECS-Nr.	RD5425000
F	8-10
HS Code	2941 90 00
Toxizität	LD50 orally in Rabbit: 3500 mg/kg

Gefahreninformationscode (GHS)

NOVOBIOCIN SODIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
crystalline
Verwenden
Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.
Verwenden
antibacterial
Verwenden
Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.
Trademarks
Albamycin (Pharmacia & Upjohn).
Clinical Use
The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.
Sicherheitsprofil
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.
läuterung methode
The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]

Novobiocinnatrium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1476-53-5, NOVOBIOCIN SODIUM SALT Verwandte Suche:

Send Inquriy