3-(1-Pyrrolin-2-yl)pyridin

Bezeichnung:3-(1-Pyrrolin-2-yl)pyridin

CAS-Nr532-12-7

Englisch Name:MYOSMINE

CBNumberCB9354452

SummenformelC9H10N2

Molgewicht146.19

MOL-Datei532-12-7.mol

Synonyma

3-(1-Pyrrolin-2-yl)pyridin

3-(1-Pyrrolin-2-yl)pyridin physikalisch-chemischer Eigenschaften

Schmelzpunkt	42-44°C
Siedepunkt	82-83°C 0,5mm
Dichte	1.12±0.1 g/cm3(Predicted)
Flammpunkt	82-83°C/0.5mm
storage temp.	2-8°C
Löslichkeit	Methanol (Slightly), Water (Sparingly)
Aggregatzustand	Solid
pka	pK1:5.26 (25°C)
Farbe	Light Beige to Dark Yellow
BRN	119254
Stabilität	Moisture, Temperature Sensitive
LogP	0.730 (est)
CAS Datenbank	532-12-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	UT7660000
HazardClass	IRRITANT, IRRITANT-HARMFUL
HS Code	29399990

Gefahreninformationscode (GHS)

MYOSMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
The alkaloids found in tobacco smoke may be separated into those which are volatile in steam and those which are non-volatile. Myosmine occurs in the former group and, although only present in small quantities, is the most fully investigated of these bases. The alkaloid is normally obtained as an oily liquid which may be crystallized. It is optically inactive and readily soluble in light petroleum or Et20. It forms a hydrochloride as a microcrystalline powder which, on sublimation yields colourless rods, m.p. ISS-8°C. The dihydrochloride, also a microcrystalline powder, yields colourless needles on sublimation, m.p. 1S0- 17 Soc. The base also furnishes a dipicrate, m.p. 182-3°C (dec.) and a dipi_x0002_crolonate, m.p. 204°C (dec.). On dehydrogenation it gives 2-(3'-pyridyl)-pyrrole (picrate, m.p. 200°C) identical with that obtained in a similar manner from nornicotine. According to Woodward and his colleagues, the alkaloid is one of several products formed when nicotine is dehydrogenated over prepared quartz at S70°C. It is readily hydrolyzed in H20 to yield 3-pyridyl-r-aminopropyl ketone, forming a crystalline phenylhydrazone, m.p. 20l-2°C.
Chemische Eigenschaften
Light Yellow Powder
Verwenden
Tobacco alkaloid

Reactant for:
Nitrosation reactions
Peroxidation reaction with hydrogen peroxide
Verwenden
mitogen
Verwenden
Myosmine is an alkaloid found in tobacco. Myosmine has been suspected to be a tobacco-independent carcinogenic source.
Definition
ChEBI: Myosmine is a member of the class of pyridines that is pyridine substituted by a 3,4-dihydro-2H-pyrrol-5-yl group at position 3. It is an alkaloid found in tobacco plants and exhibits genotoxic effects. It has a role as a plant metabolite, an EC 1.14.14.14 (aromatase) inhibitor and a mutagen. It is a pyrroline and a pyridine alkaloid.
Synthesis Reference(s)
Canadian Journal of Chemistry, 35, p. 651, 1957 DOI: 10.1139/v57-094
The Journal of Organic Chemistry, 37, p. 1635, 1972
Tetrahedron Letters, 8, p. 5185, 1967
Einzelnachweise
Spath, Wenusch, Zajic., Ber., 69, 393 (1936)
Woodward, Eisner, Haines., ibid, 69, 7S7 (1936)
Spath, Wibaut, Kesztler., ibid, 71, 100 (1938)

MYOSMINE Upstream-Materialien And Downstream Produkte

3-(1-Pyrrolin-2-yl)pyridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

532-12-7, MYOSMINE Verwandte Suche:

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