Methylnicotinat

Bezeichnung:Methylnicotinat

CAS-Nr93-60-7

Englisch Name:Methyl nicotinate

CBNumberCB1173538

SummenformelC7H7NO2

Molgewicht137.14

MOL-Datei93-60-7.mol

Synonyma

Methylnicotinat

Methylnicotinat physikalisch-chemischer Eigenschaften

Schmelzpunkt	42-44 °C (lit.)
Siedepunkt	204 °C (lit.)
Dichte	1.2528 (rough estimate)
chüttdichte	600kg/m3
Dampfdruck	0.4 hPa (25 °C)
Brechungsindex	1.5323 (estimate)
FEMA	3709 \| METHYL NICOTINATE
Flammpunkt	204 °F
storage temp.	Store below +30°C.
Löslichkeit	H₂O: 0.1 g/mL, clear
pka	pKa 3.1 (Uncertain)
Aggregatzustand	Crystals or Crystalline Powder
Farbe	White to brownish
Geruch (Odor)	at 10.00 % in dipropylene glycol. warm herbal tobacco
Geruchsart	herbal
Biologische Quelle	synthetic
Wasserlöslichkeit	NEGLIGIBLE
Merck	14,6100
JECFA Number	1320
BRN	113951
InChIKey	YNBADRVTZLEFNH-UHFFFAOYSA-N
LogP	0.68 at 25℃
CAS Datenbank	93-60-7(CAS DataBase Reference)
NIST chemische Informationen	Methyl nicotinate(93-60-7)
EPA chemische Informationen	Methyl nicotinate (93-60-7)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-36/38
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	QT1925000
TSCA	Yes
HS Code	29333999
Toxizität	LD50 orally in Rabbit: > 2000 mg/kg

Gefahreninformationscode (GHS)

Methyl nicotinate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Methyl nicotinate is a skin irritant in man, in particular producing vasodilatation, which is used on purpose in “rubefacient”, to produce a redness or inflammation for a short period of time, often in lip plumper or other lip products. Methyl nicotinate is also an active ingredient of a number of veterinary preparations intended for topical application as a rubefacient for the treatment of a variety of diseases, such as respiratory diseases, vascular disorders (oedema, haematoma), and rheumatoid disorders in cattle and horses (doses not stated; the concentration in the formulated veterinary medicinal product is 2%).
Chemische Eigenschaften
Methyl nicotinate is white to brownish crystals or crystalline powder and has a fresh, caramellic, nutty and mild tobacco odor.
Occurrence
Reported found in ground coffee, roasted filberts, guanabana (Annona muicata L.), roasted peanuts, wild strawberries, vanilla bean, papaya, guava, plum, beer cognac, soursop, malt, wort, Bourbon vanilla and mountain papaya.
Verwenden
Methyl nicotinate (MN) is the methyl ester of nicotinic acid that is used as an active ingredient, a rubefacient and counter-irritant in over-the-counter topical preparations indicated for the temporary relief of aches and pains in muscles,tendons, and joints. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.For veterinary purposes，methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.Methyl nicotinate can be found in in guava fruit, papaya, strawberry, soursop(Annona muricata), beer, grape brandy, coffee, roasted filbert, roasted peanut and Bourbon vanilla.
Application
Methyl nicotinate can be employed as a precursor in the synthesis:
Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains.
5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives.
synthetische
Methyl nicotinate was prepared by esterification of nicotinic acid by refluxing with methanol in the presence of concentrated sulphuric acid, esterification product obtained was extracted into organic solvent (chloroform) after neutralization of the reaction mixture with 10% sodium bicarbonate.
Synthesis and antinociceptive activity of methyl nicotinate
DOI:10.4314/jpb.v12i1.8
Definition
ChEBI: Methyl nicotinate is a member of pyridines and an aromatic carboxylic acid.
Allgemeine Beschreibung
Methyl nicotinate (or nicotinic acid methyl ester) is used as a rubefacient for the relief of pains in muscles, tendons, and joints. It is also used in food as a flavoring agent.
Nebenwirkungen
There is presently no side effect information available for Methyl nicotinate(MN) itself. a few patients who applied a medicated topical preparation containing MN (and other components) suffered adverse reactions including faintness, nausea, pain and skin rashes.
Sicherheit(Safety)
No data are available for chronic toxicity of Methyl nicotinate(MN) in humans. No adverse effects were reported for nicotinamide in clinical studies, whereas high doses of NA (3000 mg/day) are associated with considerable toxicity. In one third to one half of the 1119 patients taking 3000 mg NA /day for at least five years (to reduce the incidence of a second myocardial infarction), side effects included gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash ("The Coronary Drug Project", 1975, cited in "monograph of methyl nicotinate", Council of Europe, 2008, pp. 248).
Synthese
Methyl nicotinate is synthesized from Nicotinyl chloride hydrochloride and and Methanol in presence of Pyridine.
Carcinogenicity
No data on the mutagenic or carcinogenic potential of methyl nicotinate were presented. However life-time studies in mice employing doses of 2 to 3 mg nicotinamide/kg bw/day gave no indication of carcinogenic potential.

Methyl nicotinate Upstream-Materialien And Downstream Produkte

Methylnicotinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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