Methyl-3-pyridylketon

Bezeichnung:Methyl-3-pyridylketon

CAS-Nr350-03-8

Englisch Name:3-Acetylpyridine

CBNumberCB9286704

SummenformelC7H7NO

Molgewicht121.14

MOL-Datei350-03-8.mol

Synonyma

Methyl-3-pyridylketon

Methyl-3-pyridylketon physikalisch-chemischer Eigenschaften

Schmelzpunkt	11-13 °C (lit.)
Siedepunkt	220 °C (lit.)
Dichte	1.102 g/mL at 25 °C (lit.)
Dampfdruck	0.3Pa at 20℃
FEMA	3424 \| 3-ACETYLPYRIDINE
Brechungsindex	n20/D 1.534(lit.)
Flammpunkt	302 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pka	pK1: 3.256(+1) (25°C)
Aggregatzustand	Liquid
Farbe	Clear colorless to yellow
Wichte	1.102
PH	6.5-7.5 (H2O, 20℃)
Geruch (Odor)	at 1.00 % in dipropylene glycol. sweet nutty dry hawthorn phenolic woody popcorn
Geruchsart	nutty
Wasserlöslichkeit	SOLUBLE IN HOT WATER
Merck	14,6116
JECFA Number	1316
BRN	107751
InChIKey	WEGYGNROSJDEIW-UHFFFAOYSA-N
LogP	0.34 at 13℃
CAS Datenbank	350-03-8(CAS DataBase Reference)
NIST chemische Informationen	Ethanone, 1-(3-pyridinyl)-(350-03-8)
EPA chemische Informationen	Ethanone, 1-(3-pyridinyl)- (350-03-8)

Sicherheit

Kennzeichnung gefährlicher	T,Xi,Xn
R-Sätze:	25-36/38-36/37/38-20/21/22
S-Sätze:	45-37/39-28A-26-36
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS-Nr.	OB5425000
F	8-10
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29333999
Toxizität	LD50 orl-rat: 46 mg/kg JACTDZ 1,681,92

Gefahreninformationscode (GHS)

3-Acetylpyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/38:Reizt die Augen und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
clear colorless to yellow liquid
Chemische Eigenschaften
A colorless liquid with sweet, nutty, popcorn-like aroma
Occurrence
Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.
Verwenden
Used in the fragrance industry and as an intermediate in the synthesis of a number of clinical drugs, including Imatinib, Mesylate, Metyrapone, Telithromycin, and Ridogrel. An analog of nicotinamide that competes for incorporation into NAD. It has been used to chemically lesion the inferior olive nucleus, thereby eliminating climbing fibers within the cerebellar cortex.
Verwenden
3-Acetylpyridine used as an intermediate for the synthesis of risedronate sodium, inhibitor of bone resorption. It is also used in perfumery.
synthetische
Dry distillation of calcium nicotinate with calcium acetate.
Definition
It is a nicotinic acidantagonist.
Vorbereitung Methode
Produced from Ethyl nicotinate and Ethyl acetoacetate, in principle by hydrolysis of Aceto acetylpyridine.
Sicherheitsprofil
Poison by ingestion. Moderately toxic by intraperitoneal routeMutation data reported. A flammable liquid. When heated to decomposition emits toxic fumes of NOx,. See also KETONES
läuterung methode
It is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]

3-Acetylpyridine Upstream-Materialien And Downstream Produkte

Methyl-3-pyridylketon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

350-03-8, 3-Acetylpyridine Verwandte Suche:

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