N2-[(1,1-Dimethylethoxy)carbonyl]-L-lysin

Bezeichnung:N2-[(1,1-Dimethylethoxy)carbonyl]-L-lysin

CAS-Nr13734-28-6

Englisch Name:Boc-Lys-OH

CBNumberCB9345067

SummenformelC11H22N2O4

Molgewicht246.3

MOL-Datei13734-28-6.mol

Synonyma

N2-[(1,1-Dimethylethoxy)carbonyl]-L-lysin

N2-[(1,1-Dimethylethoxy)carbonyl]-L-lysin physikalisch-chemischer Eigenschaften

Schmelzpunkt	~205 °C (dec.)(lit.)
alpha	22 º (c=2, CH3OH)
Siedepunkt	389.3°C (rough estimate)
Dichte	1.1313 (rough estimate)
Brechungsindex	21.5 ° (C=2, MeOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Acetic Acid (Slightly), Methanol (Slightly, Sonicated), Water (Slightly, Heated,
pka	3.92±0.21(Predicted)
Aggregatzustand	Powder
Farbe	White
Optische Aktivität	[α]20/D +4.6±0.5°, c = 2% in H2O
Wasserlöslichkeit	Soluble in water. Slightly soluble in methanol.
BRN	4252546
InChI	InChI=1S/C11H22N2O4/c1-11(2,3)17-10(16)13-8(9(14)15)6-4-5-7-12/h8H,4-7,12H2,1-3H3,(H,13,16)(H,14,15)/t8-/m0/s1
InChIKey	DQUHYEDEGRNAFO-QMMMGPOBSA-N
SMILES	C(O)(=O)[C@H](CCCCN)NC(OC(C)(C)C)=O
CAS Datenbank	13734-28-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	24/25-36-26
WGK Germany	3
HS Code	2924 19 00
HazardClass	IRRITANT

Gefahreninformationscode (GHS)

Boc-Lys-OH Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to off-white powder
Verwenden
Boc-Lys-OH (Nα-Boc-L-lysine) can be used as a building block to synthesize:
A heterotrifunctional peptide-based linker molecule applicable as a bio-labeling reagent.
Lysine derivatives of azamacrocycle and anthraquinone.
Boc-Lys(Bn4-DTPA)-OH, a precursor to synthesize diethylene triamine pentaacetic acid (DTPA) containing peptides.
A ferrocene-amino acid conjugate which is used in developing chemical warfare agent (CWA) sensor.
Verwenden
N-Boc-L-lysine is a protected analogue of a major amino acid participating in the binding of AcH to proteins. N-Boc-L-lysine as well as other t-butoxycarbonyl (Boc) amino acids can be converted to their respective amino acids via cleavage of the urethane bond.
Vorbereitung Methode
L-lysine was added to acetone and Et3N under stirring at 25 °C. After that, di-tert-butyl dicarbonate was added. After 4.5 h, decompression evaporates acetone, and the water layer is extracted with ethyl ether 3 times. The dilute HC1 was added to the aqueous layer to adjust pH 2-3. The crude product was purified to obtain Boc-Lys-OH.
reaction suitability
Boc solid-phase peptide synthesis

Boc-Lys-OH Upstream-Materialien And Downstream Produkte

N2-[(1,1-Dimethylethoxy)carbonyl]-L-lysin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

13734-28-6, Boc-Lys-OH Verwandte Suche:

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