(R)-(+)-1-(4-Methylphenyl)ethylamine Struktur

(R)-(+)-1-(4-Methylphenyl)ethylamine

Bezeichnung:(R)-(+)-1-(4-Methylphenyl)ethylamine

CAS-Nr4187-38-6

Englisch Name:(R)-(+)-1-(4-Methylphenyl)ethylamine

CBNumberCB9311444

SummenformelC9H13N

Molgewicht135.21

MOL-Datei4187-38-6.mol

(R)-(+)-1-(4-Methylphenyl)ethylamine physikalisch-chemischer Eigenschaften

Schmelzpunkt	<-20°C
Siedepunkt	205 °C (lit.)
alpha	37 º (NEAT)
Dichte	0.919 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.521(lit.)
Flammpunkt	180 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	9.20±0.10(Predicted)
Wichte	0.919
Optische Aktivität	[α]20/D +37°, neat
Sensitive	Air Sensitive
BRN	3195425
CAS Datenbank	4187-38-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	20/21/22-34
S-Sätze:	16-26-27-36/37/39-45
RIDADR	UN 2619 8/PG 2
WGK Germany	3
HazardClass	8
PackingGroup	III
HS Code	2921490090

Gefahreninformationscode (GHS)

(R)-(+)-1-(4-Methylphenyl)ethylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Colorless to light yellow liquid
Verwenden
(R)-(+)-α,4-Dimethylbenzylamine can be used as a chiral salt of keto acid, employed in the solid-state photolysis studies of α-mesitylacetophenone derivatives.
Application
(R)-(+)-α,4-Dimethylbenzylamine reacts with 1,5-difluoro-2,4-dinitrobenzene (DFDNB) to form a chiral derivative reagent(CDR) via substitution of one fluorine atom.
Allgemeine Beschreibung
(R)-(+)-α,4-Dimethylbenzylamine is a chiral amine.
Synthese
(R)-(+)-1-(4-methylphenyl)ethylamine was synthesized via a series of chemical reactions with (R)-N-[1-(4-methylphenyl)ethyl]acetamide. The steps are as follows:
1 g of the compound obtained in the previous stage will be used. 2 g of n-butanol was added, 0.63 g of potassium hydroxide was added, and the temperature was raised to 100 ° C. After 24 hours of heat preservation, cool down to 10 to 20 ℃. After adding water and stirring for 0.5 hours, the mixture was allowed to stand for separation, and the organic layer was concentrated to n-butanol, and then subjected to vacuum distillation (80-100 ℃ packed column) to obtain (R)-1-(4-methylphenyl)ethylamine 0.63 g. The yield was 82%, the HPLC purity was 96.3%, and the enantiomer was 0.8%.
structure and hydrogen bonding
(R)-(+)-1-(4-Methylphenyl)ethylamine is a chiral molecule studied in the context of crystallographic analysis and optimization. Through X-ray diffraction analysis, the crystal structure of (R)-(+)-1-(4-Methylphenyl)ethylamine was determined, revealing the presence of a significant hydrogen bond between the amine group and one of the carbonyl groups. This hydrogen bond plays a crucial role in stabilizing the (R)-(+)-1-(4-Methylphenyl)ethylamine molecule, which is a recurring pattern observed in structurally similar compounds. Furthermore, the (S)-(+)-enantiomer of (R)-(+)-1-(4-Methylphenyl)ethylamine was synthesized using an enantiopure precursor, establishing an efficient method to obtain this desired form of the molecule.

(R)-(+)-1-(4-Methylphenyl)ethylamine Upstream-Materialien And Downstream Produkte

(R)-(+)-1-(4-Methylphenyl)ethylamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4187-38-6, (R)-(+)-1-(4-Methylphenyl)ethylamine Verwandte Suche:

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