5-α-Cholestan-3-β-ol

Bezeichnung:5-α-Cholestan-3-β-ol

CAS-Nr80-97-7

Englisch Name:Dihydrocholesterol

CBNumberCB9262856

SummenformelC27H48O

Molgewicht388.68

MOL-Datei80-97-7.mol

Synonyma

5-α-Cholestan-3-β-ol

5-α-Cholestan-3-β-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	138-142 °C
alpha	D22 +24.2° (c = 1.3 in chloroform)
Siedepunkt	454.32°C (rough estimate)
Dichte	0.9506 (rough estimate)
Brechungsindex	1.5250 (estimate)
storage temp.	-20°C
Löslichkeit	chloroform: 0.1 g/mL, clear, colorless
Aggregatzustand	A solid
pka	15.14±0.70(Predicted)
Farbe	White to off-white
Wasserlöslichkeit	Insoluble in water.
Merck	14,2200
BRN	2418594
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents.
LogP	10.065 (est)
CAS Datenbank	80-97-7(CAS DataBase Reference)
NIST chemische Informationen	Cholestanol(80-97-7)
EPA chemische Informationen	Dihydrocholesterol (80-97-7)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-38-40-48/20/22-67-36/38-20-63
S-Sätze:	24/25-36/37-22-26
RIDADR	UN 1888 6.1/PG 3
WGK Germany	3
RTECS-Nr.	FZ6350000
TSCA	Yes
HS Code	2906 13 10

Gefahreninformationscode (GHS)

Dihydrocholesterol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R38:Reizt die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R48/20/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen und durch Verschlucken.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S22:Staub nicht einatmen.
Beschreibung
Cholestanol is a cholesterol metabolite formed by oxidation and an intermediate in the biosynthesis of chenodeoxycholic acid . Cholestanol (10 μg/ml) induces apoptosis in cornea and lens epithelial cells and increases the activity of IL-1β converting enzyme (ICE) and CPP32 proteases. Dietary administration of 1% cholestanol to mice increases serum and liver cholestanol levels and leads to corneal opacities and gallstones and in rats it leads to cholestanol deposition in the cerebellum. Cholestanol levels are increased in plasma of patients with cerebrotendinous xanthomatosis (CTX), a disease characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.
Chemische Eigenschaften
white powder
Verwenden
5alpha-Cholestan-3beta-ol is used as a standard in lipid analysis using HPLC. It acts as a derivitized steroid compound. It is used in agrochemical, pharmaceutical and dyestuff field .
Verwenden
5α-Cholestan-3β-ol is a carbon stanol formed from biohydrogenation of Cholesterol (C432501) in the gut. Studies have also examined the conversion of 5α-Cholestan-3β-ol catalyzed by 3-β-hydroxysteroid dehydrogenase of rat liver.
Definition
ChEBI: A cholestanoid that is (5alpha)-cholestane substituted by a beta-hydroxy group at position 3.
Allgemeine Beschreibung
Cholestanol is a 5α-dihydro derivative of cholesterol. It acts as a marker for cholesterol absorption. Cholestanol is a steroid with 27 carbon atoms.
Biochem/physiol Actions
5α-Cholestan-3β-ol is derived from cholesterol by the action of intestinal microorganisms. It is known to induce the formation of gall stones in rabbits in the presence of sodium ions.
läuterung methode
Purify 5--cholestan-3-ol via acetylation, crystallisation and de-acetylation, then recrystallisation from EtOH or slightly aqueous EtOH, or MeOH. Its solubility is: 0.5% (MeOH) and 1% (EtOH) at 25o. [Mizutani & Whitten J Am Chem Soc 107 3621 1985.] The acetate has m 114-115o from EtOAc/MeOH and, [] D 20 +13o (c 2, CHCl3). [Bruce & Ralls Org Synth Col Vol II 191 1943, Beilstein 6 IV 3577.]

Dihydrocholesterol Upstream-Materialien And Downstream Produkte

5-α-Cholestan-3-β-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

80-97-7, Dihydrocholesterol Verwandte Suche:

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