4-Cholesten-3-one Struktur

Cholest-4-en-3-on

Bezeichnung:Cholest-4-en-3-on

CAS-Nr601-57-0

Englisch Name:4-Cholesten-3-one

CBNumberCB3222827

SummenformelC27H44O

Molgewicht384.64

MOL-Datei601-57-0.mol

Synonyma

Cholest-4-en-3-on

Cholest-4-en-3-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	79-82 °C
alpha	92.5 º (c=2, CHCl3)
Siedepunkt	451.27°C (rough estimate)
Dichte	0.9717 (rough estimate)
Brechungsindex	1.5100 (estimate)
storage temp.	-20°C
Löslichkeit	Chloroform (Sparingly), Methanol (Slightly, Heated)
Aggregatzustand	Solid
Farbe	White to Off-White
Optische Aktivität	[α]23/D +91.0°, c = 2 in chloroform
Wasserlöslichkeit	<0.5 g/L
BRN	4707774
Stabilität	Stable. Incompatible with strong oxidizing agents.
CAS Datenbank	601-57-0(CAS DataBase Reference)
NIST chemische Informationen	Cholest-4-en-3-one(601-57-0)
EPA chemische Informationen	Cholest-4-en-3-one (601-57-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-24/25-36-26
WGK Germany	3
RTECS-Nr.	FZ7700000
TSCA	Yes
HS Code	29142900

Gefahreninformationscode (GHS)

4-Cholesten-3-one Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Cholestanone is a cholesterol metabolite that has a keto group in place of the 3-hydroxy group on cholesterol. It decreases TGF-β-induced Smad2 phosphorylation and TGF-β expression and prevents inhibition of DNA synthesis by TGF-β in Mv1Lu cells when used at a concentration of 50 μg/ml. Increased fecal excretion of cholestenone is correlated with an increased risk of colorectal cancer. Cholestenone reduces serum cholesterol levels in a variety of animal models but is toxic to rats when administered at doses of 700-1,000 mg/kg per day, inducing hypertrophy in and reducing the activity of the adrenal gland. It has been used as synthetic intermediate in the synthesis of steroids.
Chemische Eigenschaften
white to light yellow crystals or powder
Verwenden
4-Cholesten-3-one is used as a chiral building block for proteomics research. It is an intestinal metabolite of cholesterol and exhibits an anti-obesity effect on animals.
Definition
ChEBI: Cholest-4-en-3-one is a cholestanoid that is cholest-4-ene substituted by an oxo group at position 3. It has a role as a human metabolite and a plant metabolite. It is a cholestanoid and a 3-oxo-Delta(4) steroid.
Allgemeine Beschreibung
Cholestenone is a cholesterol metabolite and analog, which substitutes membrane cholesterol and elevates membrane fluidity.

4-Cholesten-3-one Upstream-Materialien And Downstream Produkte

Cholest-4-en-3-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

601-57-0, 4-Cholesten-3-one Verwandte Suche:

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