Isoliquiritigenin

Bezeichnung:Isoliquiritigenin

CAS-Nr961-29-5

Englisch Name:Isoliquiritigenin

CBNumberCB9131280

SummenformelC15H12O4

Molgewicht256.25

MOL-Datei961-29-5.mol

Isoliquiritigenin physikalisch-chemischer Eigenschaften

Schmelzpunkt	206-210°C
Siedepunkt	504.0±42.0 °C(Predicted)
Dichte	1.384±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	H₂O: <0.1 mg/mL
pka	7.50±0.35(Predicted)
Aggregatzustand	powder
Farbe	yellow to orange
Sensitive	Light Sensitive & Hygroscopic
BRN	1914296
InChIKey	DXDRHHKMWQZJHT-FPYGCLRLSA-N
LogP	3.110 (est)
CAS Datenbank	961-29-5(CAS DataBase Reference)

Sicherheit

R-Sätze:	36/37/38
S-Sätze:	26-37
WGK Germany	3
RTECS-Nr.	FL7080000
HS Code	29145090

Gefahreninformationscode (GHS)

Isoliquiritigenin Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Yellow solid
Verwenden
aldose reductase inhibitor, antineoplastic, antiinflammatory
Verwenden
Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. ISL induces quinone reductase-1, a phase II enzyme that deactivates radicals and electrophiles, with a concentration required to double activity (CD) value of 1.8 μM in murine hepatoma cells.
Definition
ChEBI: Isoliquiritigenin is a member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, a biological pigment, a NMDA receptor antagonist, a GABA modulator, a metabolite, an antineoplastic agent and a geroprotector. It is functionally related to a trans-chalcone. It is a conjugate acid of an isoliquiritigenin(1-).
Allgemeine Beschreibung
Isoliquiritigenin is an aromatic ketone and belongs to the chalcone group of compound. It is derived from licorice and is a component in medicine and food.
Biochem/physiol Actions
Isoliquiritigenin is a soluble guanylyl cyclase activator and possesses antitumor activity. It also possesses antioxidant, antiplatelet and estrogenic properties.
Anticancer Research
It is extracted from Dipteryx odorata seeds, found to be active in induction of quininereductase, and thus prevents chemical carcinogenesis. In a dose- and time-dependentmanner, it significantly inhibits the proliferation of prostate cancer cells,and this isoliquiritigenin-induced cell cycle arrest and antiproliferative effects maybe manifested by growth arrest- and DNA damage-inducible gene 153 (GADD153).It induces apoptosis in prostate cancer cells through mitochondrial apoptosispathway in which mitochondrial membrane potential is disrupted, cytochrome-cand Smac/Diablo are released, and caspase-9 is activated. It is reported to enhancethe expression of universal inhibitor of cyclin-dependent kinases, p21CIP1/WAF1, in adose- and time-dependent manner in A549 human lung cancer cells (Kanazawaet al. 2003; Ii et al. 2004; Balunas and Kinghorn 2005; Jung et al. 2006).
Lager
+4°C

Isoliquiritigenin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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