3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4-benzopyron

Bezeichnung:3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4-benzopyron

CAS-Nr491-54-3

Englisch Name:ARTEMISININ

CBNumberCB0387974

SummenformelC16H12O6

Molgewicht300.26

MOL-Datei491-54-3.mol

Synonyma

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4-benzopyron

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4-benzopyron physikalisch-chemischer Eigenschaften

Schmelzpunkt	156-157 °C(lit.)
Siedepunkt	543.8±50.0 °C(Predicted)
Dichte	1.538
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
pka	6.32±0.40(Predicted)
Aggregatzustand	Solid
Farbe	Yellow
BRN	305378
LogP	2.740 (est)
CAS Datenbank	491-54-3

Sicherheit

S-Sätze:	24/25
WGK Germany	2
RTECS-Nr.	KD4170000
HS Code	29329990

Gefahreninformationscode (GHS)

ARTEMISININ Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Yellow powder
Verwenden
Kaempferide is a flavonoid that maintains anti-radical and anti-oxidant capabilities, as well as anti-tumour possibilities. Impurity of Icaritin (I163700).
Definition
ChEBI: A monomethoxyflavone that is the 4'-O-methyl derivative of kaempferol.
Biologische Aktivität
the effects of phytoestrogens have been studied in the hypothalamic-pituitary-gonadal axis and various non-gonadal targets. epidemiologic and experimental evidence indicates a protective effect of phytoestrogens also in colorectal cancer. the mechanism through which estrogenic molecules control colorectal cancer tumorigenesis could possibly involve estrogen receptor β, which is the predominantly expressed estrogen receptor subtype in colon mucosa.
in vitro
kaempferide triglycoside proved to inhibit the proliferation of native and estrogen receptor β overexpressing colon cancer cells via a mechanism not mediated by ligand binding dependent estrogen receptor activation. it affected hct8 cell cycle progression through increasing the g0/g1 cell fraction and in estrogen receptor β overexpressing cells increased two antioxidant enzymes [1].
in vivo
the aim of one previous study was to evaluate the effect of kaempferol on tissue lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal cancer in male wistar rats and to compare its efficacy with irinotecan. this study revealed that kaempferol could be safely used as a chemopreventive agent in colorectal cancer [2].
Einzelnachweise
[1] martineti v, tognarini i, azzari c, carbonell sala s, clematis f, dolci m, lanzotti v, tonelli f, brandi ml, curir p. inhibition of in vitro growth and arrest in the g0/g1 phase of hct8 line human colon cancer cells by kaempferide triglycoside from dianthus caryophyllus. phytother res. 2010 sep;24(9):1302-8.
[2] nirmala p, ramanathan m. effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats. eur j pharmacol. 2011 mar 1;654(1):75-9.

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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