1-(3-(2-Chlor-10H-phenothiazin-10-yl)propyl)-4-piperidincarboxamid

Bezeichnung:1-(3-(2-Chlor-10H-phenothiazin-10-yl)propyl)-4-piperidincarboxamid

CAS-Nr84-04-8

Englisch Name:pipamazine

CBNumberCB8938956

SummenformelC21H24ClN3OS

Molgewicht401.95

MOL-Datei84-04-8.mol

Synonyma

Pipamazin

1-(3-(2-Chlor-10H-phenothiazin-10-yl)propyl)-4-piperidincarboxamid

1-(3-(2-Chlor-10H-phenothiazin-10-yl)propyl)-4-piperidincarboxamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	about 139°
Siedepunkt	626.6±55.0 °C(Predicted)
Dichte	1.1253 (rough estimate)
Brechungsindex	1.6340 (estimate)
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	pKa 8.60(H2O,t =24±1,I=0.002) (Uncertain)
Farbe	Off-White to Pale Beige

Gefahreninformationscode (GHS)

pipamazine Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Mornidine ,Searle ,US ,1959
Verwenden
Pipamazine is a drug od the phenothiazine class which used to be used as an antiemetic.
Definition
ChEBI: Pipamazine is a member of phenothiazines.
Manufacturing Process
To a stirred and refluxing suspension of 4.95 parts of 4piperidinecarboxamide, 1 part of sodium iodide and 8.4 parts of potassium carbonate in 40 parts of butanone there are added in the course of 30 minutes 9.3 parts of 2-chloro-10-(γ-chloropropyl)phenothiazine in 40 parts ofbutanone. Stirring and refluxing are continued for 12 hours after which the mixture is cooled and filtered. The filtrate is concentrated under vacuum to give a residue which is recrystallized from a mixture of 2-propanol and petroleum ether. The 1-[γ-(2'-chloro-10'-phenothiazine)propyl]piperidine-4carboxamide thus obtained melts at approximately 139°C.
This base is dissolved in a small amount of 2-propanol and treated with a 25% solution of hydrogen chloride in 2-propanol. Upon treatment of this solution with anhydrous ether a hydrochloride precipitates as a white solid melting at about 196°C to 197°C with formation of bubbles.
Trademarks
Normetine;.
Therapeutic Function
Antiemetic
Weltgesundheitsorganisation (WHO)
Pipamazine, which is pharmacologically similar to chlorpromazine, was introduced in 1959 for the treatment of nausea and vomiting. Although it was withdrawn in 1969 by the United States FDA on grounds of lack of proof of efficacy and safety, it remains available in some countries.

pipamazine Upstream-Materialien And Downstream Produkte

1-(3-(2-Chlor-10H-phenothiazin-10-yl)propyl)-4-piperidincarboxamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

84-04-8, pipamazine Verwandte Suche:

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