Bernsteinsure, Verbindung mit 2-Chlor-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepin (1:1)

Bezeichnung:Bernsteinsure, Verbindung mit 2-Chlor-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepin (1:1)

CAS-Nr27833-64-3

Englisch Name:Loxapine succinate salt

CBNumberCB8709350

SummenformelC22H24ClN3O5

Molgewicht445.9

MOL-Datei27833-64-3.mol

Synonyma

Bernsteinsure, Verbindung mit 2-Chlor-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepin (1:1)

Bernsteinsure, Verbindung mit 2-Chlor-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepin (1:1) physikalisch-chemischer Eigenschaften

Schmelzpunkt	150-152°C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	H₂O: soluble
Aggregatzustand	solid
Farbe	white
CAS Datenbank	27833-64-3(CAS DataBase Reference)

Sicherheit

RIDADR	UN 2811 6.1 / PGII
WGK Germany	3
RTECS-Nr.	WM5750000
HS Code	29329990

Gefahreninformationscode (GHS)

Loxapine succinate salt Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades.
Beschreibung
Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α₁-adrenergic receptors (K_i values are 7, 7.7, 9.5, 12, and 31 nM for H₁, 5-HT_2A, 5-HT_2C, D₂, and α_1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.
Chemische Eigenschaften
White to Of-White Solid
Verwenden
Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.
Verwenden
choleretic
Verwenden
A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent
Trademarks
Loxapine (Mylan); Loxitane (Watson).
Toxicity evaluation
Loxapine has antagonistic action on alpha1 adrenergic, muscarinic, serotonergic, and dopaminergic receptors. It is thought to change the level of excitability in subcortical inhibitory areas of the brain by reducing the firing threshold of some polysynaptic neurons leading to seizure activity. Anticholinergic effects are also reported with loxapine intoxication.

Bernsteinsure, Verbindung mit 2-Chlor-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepin (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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