Succimer

Bezeichnung:Succimer

CAS-Nr304-55-2

Englisch Name:Succimer

CBNumberCB9142563

SummenformelC4H6O4S2

Molgewicht182.22

MOL-Datei304-55-2.mol

Synonyma

Succimer

Succimer physikalisch-chemischer Eigenschaften

Schmelzpunkt	196-198 °C (dec.)(lit.)
Siedepunkt	285.62°C (rough estimate)
Dichte	1.439 (estimate)
Brechungsindex	1.5220 (estimate)
storage temp.	-20°C
Löslichkeit	DMSO (Sparingly), Methanol (Slightly, Heated)
pka	pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
Aggregatzustand	Powder
Farbe	White to off-white
Wasserlöslichkeit	Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
Merck	14,8865
BRN	1725150
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey	ACTRVOBWPAIOHC-XIXRPRMCSA-N
CAS Datenbank	304-55-2(CAS DataBase Reference)
EPA chemische Informationen	Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36-26
WGK Germany	2
RTECS-Nr.	WM7650000
F	10-23
TSCA	Yes
HS Code	29309090
Giftige Stoffe Daten	304-55-2(Hazardous Substances Data)
Toxizität	LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)

Gefahreninformationscode (GHS)

Succimer Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.
Chemische Eigenschaften
white or off-white powder
Originator
Johnson and Johnson (J&J) (U.S.A.)
Verwenden
A water-soluble chelating agent.
Verwenden
chelating agent, antihypertensive
Verwenden
meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.
Verwenden
chelating agent, treatment of lead poisoning
synthetische
Isolate the solid complexes of trivalent lanthanide complexes with meso-2,3-Dimercaptosuccinic Acid, furan-2-carboxylic acid, meso-2,3-dimercaptosuccinic acid and sarcosine from the mixture of equimolar solutions of metal nitrates and ligands. Adjust the pH of the mixture to 7 by adding dilute solution of KOH. Reflux the mixture in ethanol (15-20 ml) for 3-4 hours on a steam bath. The clear solution gives a solid mass on cooling, filter through G4 glass crucible and wash several times with the mixture of doubly distilled water and alcohol. Recrystallise it to obtain pure crystal and dry at 60 ?? -70 ??C [1].
Definition
ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.
Trademarks
Chemet (Ovation).
Pharmazeutische Anwendungen
The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning.
Pharmazeutische Anwendungen
Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO₂CCH(SH)CH(SH)CO₂H. There are two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been successfully used for the treatment of heavy-metal poisoning.
Veterinary Drugs and Treatments
In veterinary medicine, succimer may be useful for the oral treatment of lead poisoning in small animals (including birds). Potentially, it also may be of benefit for the treatment of other toxic heavy metals such as arsenic or mercury, but more research must be done before this can be recommended.
läuterung methode
Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]

Succimer Upstream-Materialien And Downstream Produkte

Succimer Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

304-55-2, Succimer Verwandte Suche:

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