Baclofen Produkt Beschreibung

Baclofen Struktur
1134-47-0
  • CAS-Nr.1134-47-0
  • Bezeichnung:Baclofen
  • Englisch Name:Baclofen
  • Synonyma:Baclofen
    Clofen;Spinax;baclon;Lioresa;ba34647;Atrofen;c34647ba;BACLOFEN;LIORESAL;Baclofen(R)
  • CBNumber:CB8669450
  • Summenformel:C10H12ClNO2
  • Molgewicht:213.66
  • MOL-Datei:1134-47-0.mol
Baclofen physikalisch-chemischer Eigenschaften
Sicherheit
  • Kennzeichnung gefährlicher :T,Xn
  • R-Sätze: :61-25-36/37/38-42/43-20/21/22
  • S-Sätze: :53-22-36/37/39-45-52-36-26
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :3
  • RTECS-Nr. :MW5084200
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :2922492050
  • Toxizität :LD50 in male mice, rats (mg/kg): 45, 78 i.v.; 103, 115 s.c.; 200, 145 orally (Tadokoro)

Baclofen Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R61:Kann das Kind im Mutterleib schädigen.
    R25:Giftig beim Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
    R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  • S-Sätze Betriebsanweisung: S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
    S22:Staub nicht einatmen.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S52:Nicht großflächig für Wohn- und Aufenthaltsräume zu verwenden.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Chemische Eigenschaften Off-White Solid
  • Verwenden Specific GABA-B receptor agonist. Muscle relaxant (skeletal)
  • Definition ChEBI: A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.
  • Trademarks Kemstro (Schwarz Pharma); Lioresal (Medtronic); Lioresal (Novartis).
  • Biologische Funktion Baclofen (Lioresal) is the parachlorophenol analogue of the naturally occurring neurotransmitter γ-aminobutyric acid (GABA).
  • Allgemeine Beschreibung Odorless or practically odorless white to off-white crystalline powder.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen Baclofen is an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
  • Health Hazard SYMPTOMS: Symptoms of exposure to Baclofen via ingestion may include drowsiness, insomnia, dizziness, weakness, mental confusion, nausea, constipation, anorexia, urinary retention, impotence, nystagmus, diplopia and incoordination. Ingestion may lead to cholinergic effects and lassitude. It may also lead to ataxia. Other symptoms due to ingestion may include impaired renal function, fatigue, headache, hypotension, urinary frequency, rash, pruritis, ankle edema, excessive perspiration, weight gain, nasal congestion, and rarely, euphoria, excitement, depression, hallucinations, paresthesia, muscle pain, tinnitus, slurred speech, tremor, rigidity, dystonia, blurred vision, strabismus, miosis, mydriasis, dysarthia, epileptic seizure, dyspnea, palpitation, chest pain, syncope, dryness of the mouth, taste disorder, abdominal pain, vomiting, diarrhea, blood in the stools, enuresis, dysuria, inability to ejaculate, nocturia and hematuria. Overexposure through ingestion may result in seizures, and coma with respiratory depression. Aspiration pneumonia is a frequent complication of coma with respiratory depression. Other symptoms due to overdosage may include vomiting, muscular hypotonia, drowsiness, and accommodation disorders. Cyanosis has been reported. Chronic ingestion may result in drowsiness, depression, weakness, anxiety, ataxia, headaches, blurred vision, gastric upset and pruritic skin rashes characterized by urticaria or erythematous macular eruptions. Sudden withdrawal after chronic ingestion may cause auditory and visual hallucinations, anxiety and tachycardia. Seizures may also occur after sudden withdrawal. Abuse may lead to drug dependence.
  • Brandgefahr Flash point data for Baclofen are not available. Baclofen is probably combustible.
  • Biologische Aktivität Selective GABA B receptor agonist. Skeletal muscle relaxant.
  • Mechanism of action Baclofen appears to affect the neuromuscular axis by acting directly on sensory afferents, γ-motor neurons, and collateral neurons in the spinal cord to inhibit both monosynaptic and polysynaptic reflexes. The principal effect is to reduce the release of excitatory neurotransmitters by activation of presynaptic GABAB receptors. This seems to involve a G protein and second-messenger link that either increases K+ conductance or decreases Ca++ conductance.
  • Clinical Use Baclofen is an agent of choice for treating spinal spasticity and spasticity associated with multiple sclerosis. It is not useful for treating spasticity of supraspinal origin. Doses should be increased gradually to a maximum of 100 to 150 mg per day, divided into four doses.
  • Nebenwirkungen Side effects are not a major problem, and they can be minimized by graduated dosage increases.They include lassitude, slight nausea, and mental disturbances (in including confusion, euphoria, and depression). The drowsiness is less pronounced than that produced by diazepam—an important therapeutic advantage. Hypotension has been noted, particularly following overdose. Elderly patients and patients with multiple sclerosis may require lower doses and may display increased sensitivity to the central side effects. Baclofen may increase the frequency of seizures in epileptics.
  • Veterinary Drugs and Treatments Baclofen may be useful to decrease urethral resistance in dogs to treat urinary retention. It is not recommended for cats.
  • Stoffwechsel Baclofen is rapidly and effectively absorbed after oral administration. It is lipophilic and able to penetrate the blood-brain barrier.Approximately 35% of the drug is excreted unchanged in the urine and feces.
Baclofen Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Baclofen Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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1134-47-0, Baclofen Verwandte Suche:
  • 4-Amino-3-(p-chlorophenyl)butyric acid
  • Benzenepropanoic acid, β-(aminomethyl)-4-chloro-
  • CIBA Ba 34647
  • DL-4-Amino-3-p-chlorophenylbutanoic acid
  • DL-Baclofen
  • Hydrocinnamic acid, β-(aminomethyl)-p-chloro- (7CI, 8CI)
  • β-(4-Chlorophenyl)-γ-aminobutyric acid
  • β-p-Chlorophenyl-GABA
  • Baclofen(R)
  • Baclofen13C2
  • -(4-Chlorophenyl)-GABA
  • -(Aminomethyl)-4-chloro-benzenepropanoic Acid
  • (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
  • g-Amino-b-(p-chlorophenyl)butyric acid
  • β-(Aminomethyl)-4-chlorohydrocinnamic acid
  • (±)-Baclofen,(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
  • Baclofen (350 mg)
  • Baclofen (500 mg)
  • 4-AMino-3-(4-chlorophenyl)butyric Acid, Baclofen
  • Baclofen beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
  • beta-(aminomethyl)-p-chloro-hydrocinnamicaci
  • beta-(aminomethyl)-p-chlorohydrocinnamicacid
  • beta-(p-chlorophenyl)-gamma-aminobutyricacid
  • c34647ba
  • ciba34,647-ba
  • gamma-amino-beta-(p-chlorophenyl)butyricacid
  • Clofen
  • Lioresa
  • Benzenepropanoic acid, .beta.-(aminomethyl)-4-chloro-
  • BACLOFEN,USP
  • Hydrocinnamic acid, b-(aminomethyl)-p-chloro.
  • Spinax
  • Baclofen CAS NO.1134-47-0
  • -(Aminomethyl)-4-chlorobenzenpropanoicacid
  • -(p-Chlorophenyl)-aminobutyricacid
  • ba34647
  • baclon
  • beta-(4-chlorophenyl)gaba
  • beta-(aminomethyl)-4-chloro-benzenepropanoicaci
  • 4-AMINO-3-[4-CHLOROPHENYL]BUTANOIC ACID
  • 4-AMINO-3(4-CHLOROPHENYL)BUTYRIC ACID
  • (+/-)-BACLOFEN
  • BACLOFEN
  • AURORA KA-6748
  • (+/-)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID
  • (+/-)-BETA-(AMINOETHYL)-4-CHLOROBENZENEPROPANOIC ACID
  • LIORESAL
  • (RS)-4-AMINO-3-(4-CHLOROPHENYL)BUTANOIC ACID
  • (RS)-BACLOFEN
  • (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
  • Atrofen
  • beta-(4-chlorophenyl)-gamma-aminobutyric acid
  • Beta-(4-Chlorophenyl)-Gaba,Usp
  • (3RS)-4-AMINO-3-(P-CHLOROPHENYL)BUTANOIC ACID
  • (+/-)-BACLOFEN, PHARMA
  • 4-Amino-3-[Chlorophenyl] butanoic acid
  • β-[Aminomethyl]-p-chlorohydrocinnamic acid
  • (+/-)-Baclofen(USPgrade)