5-Nitropyridin-2-ol

Bezeichnung:5-Nitropyridin-2-ol

CAS-Nr5418-51-9

Englisch Name:2-Hydroxy-5-nitropyridine

CBNumberCB8401933

SummenformelC5H4N2O3

Molgewicht140.1

MOL-Datei5418-51-9.mol

Synonyma

5-Nitropyridin-2-ol

5-Nitropyridin-2-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	188-191 °C (lit.)
Siedepunkt	256.56°C (rough estimate)
Dichte	1.5657 (rough estimate)
Brechungsindex	1.4800 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Very Slightly)
pka	8.06±0.10(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	Light yellow to beige
Wasserlöslichkeit	Soluble in hot water and alkali liquor, Insoluble in most of organic solvents.
BRN	120352
InChI	InChI=1S/C5H4N2O3/c8-5-2-1-4(3-6-5)7(9)10/h1-3H,(H,6,8)
InChIKey	XKWSQIMYNVLGBO-UHFFFAOYSA-N
SMILES	C1(=O)NC=C([N+]([O-])=O)C=C1
CAS Datenbank	5418-51-9(CAS DataBase Reference)
NIST chemische Informationen	2-Hydroxy-5-nitropyridine(5418-51-9)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

2-Hydroxy-5-nitropyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
light yellow to beige crystalline powder
Verwenden
A comparison of catalysts promotes imidazolide couplings including the identification of 2-hydroxy-5-nitropyridine as a new, safe, and effective catalyst.
Synthese

4214-76-0

5418-51-9

General procedure for the synthesis of 2-hydroxy-5-nitropyridine from 2-amino-5-nitropyridine: 2-amino-5-nitropyridine (13.9 g, 0.1 mol) was dissolved in 55.6 g of 15% dilute hydrochloric acid, and 44.85 g of 20% aqueous sodium nitrite (NaNO2) was added slowly dropwise. After the dropwise addition, the reaction was continued for 6 hours. The reaction temperature was maintained at 40°C for 40 minutes. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and a light yellow solid was precipitated after cooling. The solid was washed with ice water and dried to obtain 2-hydroxy-5-nitropyridine (12.61 g), which was analyzed by high performance liquid chromatography (HPLC) with a purity of 97.69% and a yield of 88.02%.
Einzelnachweise
[1] Patent: CN105523995, 2016, A. Location in patent: Paragraph 0026; 0047; 0048
[2] Chemistry of Heterocyclic Compounds, 2002, vol. 38, # 7, p. 805 - 809
[3] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602
[4] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1914, vol. 46, p. 1240
[5] Chem. Zentralbl., 1915, vol. 86, # I, p. 1066

2-Hydroxy-5-nitropyridine Upstream-Materialien And Downstream Produkte

5-Nitropyridin-2-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5418-51-9, 2-Hydroxy-5-nitropyridine Verwandte Suche:

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