Pyridoxin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P321：Besondere Behandlung

  P405：Unter Verschluss aufbewahren.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Pyridoxine Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  crystalline solid

• Physikalische Eigenschaften

  It is one kind of B vitamins, containing pyridoxine or pyridoxal or pyridoxamine. Appearance: colorless crystals at room temperature. Solubility: soluble in water and ethanol. Stability: stable in acid liquor but easily destroyed in alkali liquor. Pyridoxol is resistant to high temperature, but pyridoxal and pyridoxamine are not.

• History

  The discovery of vitamin was tortuous and legendary. After fat-soluble A and water soluble B were discovered by the year of 1915, the discovery of vitamins entered into a rapid developed period. In separation process of riboflavin by Kuhn and his colleagues, they noticed the unusual relationship between growth-promoting activ ity and fluorescence of extracts. Then they supposed that the existence of no fluorescent substances were very necessary for growth-promoting activity of riboflavin. And they considered this phenomenon as the evidence of a second chem ical existence in the thermostable complex. At last, they named this substance as vitamin B6 .
  Vitamin B6 is widely distributed in foods, including meats, whole-grain products (especially wheat), vegetables, and nuts. In the cereal grains, vitamin B6 is concen trated primarily in the germ and aleuronic layer. Thus, the refining of grains in the production of flours, which removes much of these fractions, results in substantial reductions of vitamin B6 content. The chemical forms of vitamin B6 tend to vary among foods between plant and animal origin: plant tissues contain most pyridox ine (the free alcohol form, pyridoxol), whereas animal tissues contain most pyri doxal and pyridoxamine.

• Verwenden

  Vitamin B6, a water-soluble vitamin with a solubility of 1 g in 5 ml of water. It functions in the utilization of protein and is an essential nutrient in enzyme reactions. It is necessary for proper growth. During processing, there is a loss due to leaching of the vitamin in water. It is destroyed by high temperatures, high irradiation, and exposure to light. During storage, loss increases with temperature and storage time. It is found in liver, eggs, and meats.

• Verwenden

  antibacterial

• Verwenden

  pyridoxine HCL is a skin-conditioning agent that is also widely used in hair products.

• Indications

  Vitamin B6 deficiency

• Definition

  ChEBI: A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme f r synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.

• Trademarks

  Hexa-Betalin (Lilly).

• Weltgesundheitsorganisation (WHO)

  Pyridoxine (vitamin B6) is listed in theWHO Model List of Essential Drugs.

• Allgemeine Beschreibung

  The discovery of vitamin B₆ is generally ascribed to Paul Gy?rgy who first realized there was a vitamin that was distinctly different from vitamin B₂ in 1934. Pyridoxine (PN) is the C⁴ hydroxymethyl derivative, pyridoxal (PL) is the C⁴ formyl derivative and pyridoxamine (PM) is the C⁴ aminomethyl derivative of 5-(hydroxymethyl)- 2-methylpyridin-3-ol). Each of these are also converted to their corresponding 5'-phosphate derivatives referred to as pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP), and pyridoxamine 5'-phosphate (PMP), respectively . Because of their ability to interconvert, all are considered active forms of vitamin B₆ in vivo. Although PLP is the major coenzyme form, PMP can also function as a coenzyme primarily in aminotransferases. The major metabolite is 4-pyridoxic acid, which is excreted in the urine.

• Biologische Aktivität

  pyridoxine (pyridoxol, vitamin b6, gravidox), also known as vitamin b6, is a form of vitamin b6 found commonly in food and used as dietary supplement. pyridoxine exerts antioxidant effects in cell model of alzheimer's disease via the nrf-2/ho-1 pathway.

• Biochem/physiol Actions

  Pyridoxine plays a key role in cell maintenance and amino acid metabolism. Deficiency of vitamin B6 leads to anemia especially in pregnant women and seizures in newborns. It serves as cofactor for heme biosynthesis during δ-amino levulinic acid formation, γ-aminobutyric acid (GABA) transaminase and glutamic acid decarboxylase. Vitamin B6 also helps in reactive oxygen species (ROS) scavenging and helps plants in overcoming the abiotic and biotic stress.

• Pharmakologie

  The metabolically active form of vitamin B6 is pyridoxal phosphate, which serves as a coenzyme of numerous enzymes, most of which are involved in the metabolism of amino acids. Vitamin B6 functions through the following general mechanisms: decarboxylation, transamination, racemization, elimination, replacement reactions, and β-group interconversions.
  Pyridoxal phosphate is practically involved in all amino acid metabolism reac tions, such as transaminations, transsulfuration, and selenoamino acid metabolism, in both their biosynthesis and their catabolism. Vitamin B6 also plays an important role in the tryptophan–niacin conversion, histamine synthesis, neurotransmitter syn thesis, and hemoglobin synthesis.
  Vitamin B6 has two roles in gluconeogenesis, transaminations and glycogen uti lization. It is required for the utilization of glycogen to release glucose by serving as a coenzyme of glycogen phosphorylase.

• Clinical Use

  Pyridoxine is indicated in the treatment and prevention of known or suspected vitamin B₆ deficiency, which is most likely to occur in the setting of alcoholism in developed countries. At least seven genetic disorders that result in a vitamin B₆ deficiency syndrome in the presence of an adequate dietary intake have been identified. These result from defects in enzymes that are responsible for the bioactivation or utilization of vitamin B6.

• Sicherheitsprofil

  Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: ataxia, local anesthetic, paresthesia. When heated to decomposition it emits toxic fumes of Nox

• Veterinary Drugs and Treatments

  Pyridoxine use in veterinary medicine is relatively infrequent. It may be of benefit in the treatment of isoniazid (INH) or crimidine (an older rodenticide) toxicity. Pyridoxine deficiency is apparently extremely rare in dogs or cats able to ingest food. Cats with severe intestinal disease may have a greater requirement for pyridoxine in their diet. Experimentally, pyridoxine has been successfully used in dogs to reduce the cutaneous toxicity associated with doxorubicin containing pegylated liposomes (Doxil?). Pyridoxine has been demonstrated to suppress the growth of feline mammary tumors (cell line FRM) in vitro.
  In humans, labeled uses for pyridoxine include pyridoxine deficiency and intractable neonatal seizures secondary to pyridoxine dependency syndrome. Unlabeled uses include premenstrual syndrome (PMS), carpal tunnel syndrome, tardive dyskinesia secondary to antipsychotic drugs, nausea and vomiting in pregnancy, hyperoxaluria type 1 and oxalate kidney stones, and for the treatment of isoniazid (INH), cycloserine, hydrazine or Gyometra mushroom poisonings.

Pyridoxine Upstream-Materialien And Downstream Produkte

Pyridoxin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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