Nefazodone hydrochloride Struktur

Nefazodone hydrochloride

Bezeichnung:Nefazodone hydrochloride

CAS-Nr82752-99-6

Englisch Name:Nefazodone hydrochloride

CBNumberCB8144863

SummenformelC25H33Cl2N5O2

Molgewicht506.47

MOL-Datei82752-99-6.mol

Nefazodone hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	186-188°C
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO: ~11 mg/mL at 60 °C
Aggregatzustand	solid
Farbe	white
maximale Wellenlänge (λmax)	248nm(MeOH)(lit.)
Merck	14,6438
CAS Datenbank	82752-99-6(CAS DataBase Reference)

Sicherheit

S-Sätze:	22-24/25
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS-Nr.	XZ5483009
HS Code	2933595960

Gefahreninformationscode (GHS)

Nefazodone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT₂ receptor antagonist and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to enhance 5-HT_IA-mediated neurotransmission. Distinct from the first generation agents such as tricyclic antidepressants, nefazodone has very selective serotonergic effects with negligible affinity for cholinergic and histamine receptors, and low affinity for a₁ -adrenergic receptors. Therefore, it has a superior toxicity profile that does not produce agitation, insomnia, and lacks cardiac side effects.
Chemische Eigenschaften
White Solid
Originator
Bristol-Myers Squibb (U.S.A.)
Verwenden
A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
Verwenden
An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor
Definition
ChEBI: Nefazodone hydrochloride is a hydrochloride. It contains a nefazodone.
Manufacturing Process
Manufacturing process for Moxifloxacin hydrochloride includes these steps as follows: 1. synthesis of 1-(3-Chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride, 1-(3-Chlorophenyl)-4-(hydrazinopropyl)piperazine. 2.Phenoxypropionic acid (249.0 g, 1.50 mol) is dissolved in four equivalents of thionyl chloride (438.0 ml, 6.0 mol) and heated to reflux until the HCl evolution has ceased. The solution is then cooled to room temperature and concentrated under reduced pressure to give 281.0 g (100% yield) of phenoxypropionyl chloride as a brown oil which solidifies on cooling 3.Phenoxypropionyl chloride (9.23 g, 0.05 mol) is dissolved in 100 ml acetone and cooled with an ice bath as sodium azide (3.6 g, 0.055 mol) in 10 ml water is added dropwise. After addition is completed, the reaction mixture is warmed to room temperature and stirred for 30 minutes. The solution is decanted and concentrated. The residue is dissolved in 100 ml ether and washed with saturated sodium bicarbonate and brine. The organic phase is separated, dried (MgSO4) and concentrated to give 6.52 g (68.0% yield) of phenoxypropionyl azide as a yellow oil which solidifies on cooling. 4.Synthesis of Ethyl phenoxypropionate, Phenoxypropionyl hydrazide, Phenoxyethyl isocyanate, 2-3-(4-[3-Chlorophenyl]-1-piperazinyl)propyl]-4-(2-phenoxyethyl)- semicarbazide), and 2-[3-4-(3-Chlorophenyl)-1-piperazinyl]-propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one monohydrochloride (Nefazodone monohydrochloride).
Trademarks
Serzone (Bristol-Myers Squibb).
Therapeutic Function
Antidepressant
Allgemeine Beschreibung
Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike^; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.
Biologische Aktivität
Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.
Biochem/physiol Actions
Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

Nefazodone hydrochloride Upstream-Materialien And Downstream Produkte

Nefazodone hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

82752-99-6, Nefazodone hydrochloride Verwandte Suche:

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